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1、降脂治療對高血壓患者動脈脈搏波傳導(dǎo)速度的影響【摘要】目的:觀察降脂治療對輕中度高血壓患者動脈脈搏波傳導(dǎo)速度(PWV)的影響,并探討其機制。方法:選擇2013年2-10月本院收治的120例無高脂血癥的輕屮度高血壓患者作為研究對象,采用隨機數(shù)字表法分為降脂組和對照組,每組60例,兩組患者均給予硝苯地平緩釋片、繃沙坦控制血壓,降脂組在此基礎(chǔ)上加用阿托伐他汀鈣降脂治療,療程12個月。觀察比較治療前后兩組血壓、臂踝動脈脈搏波傳導(dǎo)速度(baPWV)、血脂水平、高敏C反應(yīng)蛋白(hs-CRP)和血漿內(nèi)皮素(ET)的變化。結(jié)果:兩組治療前baPWV.E
2、T.hs-CRP水平均高于正常值,比較差異均有統(tǒng)計學(xué)意義(P〈0.05);治療后,兩組SBP、DBP、baPWV.ET及hs-CRP水平均優(yōu)于治療前,降脂組TC及LDL-C水平均優(yōu)于治療前,降脂組TC.LDL-C.baPWV.ET及hs-CRP水平均優(yōu)于對照組,以上比較差異均有統(tǒng)計學(xué)意義(P〈0.05)o結(jié)論:對輕中度高血壓患者,在控制血壓基礎(chǔ)上,加用降脂治療,可進一步改善患者的baPWV,降低hs-CRP和ET水平,對改善患者的血管功能狀態(tài)有積極的臨床意義?!娟P(guān)鍵詞】脈搏波傳導(dǎo)速度;高敏C反應(yīng)蛋口;內(nèi)皮索;高血壓??;咼脂血癥Effe
3、ctofLipid-loweringTherapyonArteryPulseWaveConductionVelocityinPatientswithllypertension/LIAOYi~hua,DENGYun-mei,MAYanTi,etal.//MedicalInnovationofChina,2015,12(29):062-065[Abstract]Objective:Toobservetheeffectoflipid-loweringtherapyonpulsewavevelocityinpatientswithmildto
4、moderatehypertensionandtoexploreitsmechanism.Method:120miIdtomoderatehypertensionpatientswithout,hyperlipidemiainourhospitalfromFebruarytoOctober2013wereselectedandrandomlydividedintothecontrolgroupandthelipid-loweringgroup,eachgrouphad60patients.Allpatientsofthetwogrou
5、psweregivenNifedipineandValsartantocontrolthebloodpressure,thelipid-loweringgroupwasgivenAtorvastatintoreducelipidonthebasisoftheabovetreatment.Thetherapeuticcoursewas12months?Thebloodpressure,brachialanklepulsewavevelocity(baPWV),bloodlipidlevels,highsensitiveCreactive
6、protein(hs~CR卩)andendothelin(ET)ofthetwogroupsweredetectedandcomparedbeforeandaftertreatment.Result:Beforetreatment,thelevelsofbaPWV,ETandhs~CR卩ofthetwogroupswereallhigherthanthenormalranges,thedifferenceswerestatisticallysignificant(P<0.05).ThelevelsofSBP,DBP,baPWV,ETa
7、ndhs-CRPofthetwogroupsaftertreatmentwereal1betterthanthosebeforetreatment.ThelevelsofTCandLDL-Cofthelipid-loweringgroupaftertreatmentwerebetterthanthosebeforetreatment.ThelevelsofTC,LDL-C,baPWV,ETandhs-CRPofthelipid-loweringgroupwerebetterthanthoseofthecontrolgroup.Thed
8、ifferencesabovewereallstatisticallysignificant(P<0.05).Conclusion:Forpatientswithmildtomoderatehypertension,an