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1、NOTEVirologyTheInfectivityandPathogenicityofaGroup2BovineCoronavirusinPupsTakashiKANESHIMA1),TsutomuHOHDATSU1)*,RyokoHAGINO1),SakikoHOSOYA1),YuiNOJIRI1),MichikoMURATA1),TomomiTAKANO1),MakiTANABE1),HiroshiTSUNEMITSU2)andHiroyukiKOYAMA1)1)DepartmentofVeterinaryInfectiousDisease,SchoolofVeterinaryMed
2、icineandAnimalScience,KitasatoUniversity,Towada,Aomori034–8628and2)ViralDiseasesResearchTeam,NationalInstituteofAnimalHealth,Tsukuba,Ibaraki305–0856,Japan(Received19July2006/Accepted17November2006)ABSTRACT.Caninerespiratorycoronavirus(CRCoV),whichismorecloselyrelatedtothebovinecoronavirus(BCoV),ha
3、srecentlybeendetectedindogs.Inthisstudy,weexaminedwhetherBCoVwascapableofinfectingandexhibitingpathogenicityindogs.Three1-month-oldpupswereoronasallygivenfieldisolatesofBCoV,andwerekepttogetherwith2controlanimals.Asaresult,increasesinBCoV-neutralizingantibodytiterswereconfirmedinallpupsinthechalle
4、ngedandcontrolgroups.Moreover,thevirusgenewasalsodetectedinoralandrectalswabsbyRT-PCR.TheseresultsindicatethatBCoVinfectsdogs,andeasilyinfectsotherdogsthatarekepttogether.However,noclinicalsymptomssuchasrespiratorysymptomsanddiarrheawereobserved.KEYWORDS:BCoV,Coronavirus,CRCoV.J.Vet.Med.Sci.69(3):
5、301–303,2007Caninecoronavirus(CCoV)isknownasacausativeInthisstudy,weinoculatedthree1-month-oldpupswithagentofmoderatetosevereenteritisinyoungpups[14].BCoVoronasally,andexaminedwhetherBCoV1)infectedCCoV,felinecoronavirus(FCoV),transmissiblegastroen-thepups,and2)causedrespiratoryorgastrointestinalsy
6、mp-teritisvirus(TGEV),humancoronavirusstrain229E,andtomsinthem.Inaddition,wekeptthese3pupstogetherporcineepidemicdiarrheavirusareclassifiedasgroup1with2controlpupstoexaminewhethertheBCoVinfectioncoronaviruses[11].However,ithasrecentlybeenreportedbecameestablishedinthecontrolpups.intheUnitedKingdom
7、thatthegroup2coronavirusgene,Five1-month-old,coronavirusantibody-negativebeaglewhichismorecloselyrelatedtothoseofbovinecoronaviruspupsthathadbeenkeptinatemperature-controlled,isolated(BCoV)andhumancoronavirusstra
