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1、152:1,2015ESVP/ECVPProceedings201253dorsalhoofwallandlaminae,solarwallandthirdphalanx.SectionsIntroduction:Anewcoronavirus(CoV),MiddleEastrespiratorywerestainedwithhaematoxylinandeosinandWarthin-Starry.syndromeCoV(MERS-CoV),iscausinganongoingoutbreakinResults:Theearlystageofthediseas
2、eisrepresentedbydermatitisofpeople,sometimesresultinginsevereorevenfatalpneumonia.thedigitalskinandcoronarybandandispredominantlylymphoplas-MERS-CoVusesdipeptidylpeptidase4(DPP4)asafunctionalre-macytic.Inthemostseverestage,thecorni?edlayerofthedorsalceptorandisabletoinfectcellsofalim
3、itednumberofanimalspecieshoofwallexhibitsseveresuppurativein?ammation,haemorrhageincludingbats,camels,goatsandnon-humanprimatesinvitro,butsoandintralesionalbacteria,andthereisseparationofthehoofwallfarthereisnogoodanimalmodelforhumandisease.Becausethevi-fromtheunderlyinglaminae.Inthe
4、later,healingstagesofthedis-rusbindingregioninrabbitDPP4closelyresemblesthatinhumanease,thehoofwallre-grows,butisoftendeformed.Milderhistologi-DPP4,wetestedwhetherrabbitscanbeinfectedwithMERS-CoVcallesionsoflymphoplasmacyticdermatitisofthecoronarybandandasananimalmodelforMERS-CoVinfe
5、ctioninman.suppurativein?ammationofthehornremain.ThedorsalaspectofMaterialsandMethods:Sixteenrabbits,serologicallynegativeforthethirdphalanxexhibitsamoderatedegreeofperiostealactivationMERS-CoV,wereinoculatedwithMERS-CoVorshaminoculumandosteophyteformation.Warthin-Starrystainingrevea
6、lsthepres-vianoseandtracheaandswabsweretakenfrequently.TherabbitsenceofspirochaetalorganismsmorphologicallyconsistentwithTrep-werekilled3,4or21days(n54perday)afterinoculationanddur-onemaspp.ingnecropsyexaminationsamplesweretakenforpathology,immu-Conclusions:Thisisthe?rstdescriptionof
7、thepathologicalchangesnohistochemistry,in-situhybridizationandvirology.ofCODD,anddemonstratesthepresenceofwhatisconsideredtheResults:Therabbitshadnoclinicalsignsand3or4daysafterinoc-mostlikelyaetiologicalagent(i.e.Treponemaspp.).ulation.TheyhadhighviralloadsasdeterminedbyPCRandscat-t
8、eredvirusant
