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1、第24卷第l2期化學(xué)研究與應(yīng)用Vo1．24，No．122012年12月ChemicalResearchandApplicationDee．，2012文章編號(hào)：1004-1656(2012)12—1840-05Asymmetricsynthesisofchiral-aminophosphonatesviahydrosflylationcatalyzedbychiralsulfinamideFANGHui．一，CAIXian-rong，SUNJian’’(1．NaturalProductsResearchCenter，ChengduInstituteo
2、fBiology，ChineseAcademyofSciences，Chengdu610041，China；2．GraduateSchoolofChineseAcademyofSciences，Beijing100039，China)AbstractiThefirstorganocatalytiemethodhadbeendevelopedfortheasymmetricreductionoffl-aminophosphonatesusingchiralsulilnamidesascatalystandtriehlorosilane鵲reducin
3、gagent，whichfurnishedtheusefulproductsehiral·aminophosphonateswithhig}lyieldsandg0odenantioselectivities．Keywords：#-aminophosphonate；asymmetrichydresilylation；trichlorosilane；organocatalysis；enantioselectivity中圖分類號(hào)：0627．5文獻(xiàn)標(biāo)識(shí)碼：A手性亞磺酰胺催化不對(duì)稱硅氫化合成手性一氨基膦酸酯方輝2，蔡顯榮，孫健h(1．中國(guó)科學(xué)院成都生物研究
4、所，四川成都610041；2．中國(guó)科學(xué)院研究生院，北京100039)關(guān)鍵詞：以手性亞磺酰胺作為催化劑，三氯硅烷為還原劑，發(fā)展了通過(guò)有機(jī)小分子催化合成有用的手性氨基膦酸酯的方法，獲得了較好的產(chǎn)率和對(duì)映選擇性。中圖分類號(hào)：屆-氨基膦酸酯；不對(duì)稱硅氫化；三氯硅烷；有機(jī)催化；對(duì)映選擇性Chiral盧-aminophosphonicacidsandtheirde-Bemeretalreportedthefirstcatalyticmethodthatrivativesareanimportantclassofcompounds，whichpromotedth
5、easymmetrichydrogenationof—enaminohavebeenfrequentlyusedashioisosteresofaminophosphonateswithhighyieldsandenanfioselectivitiesacidsinthedesignofbiochemicallyandpharmaceuti-(<92％8e)usingchiralRh．complexascatalyst．callyusefulmolecules[剖．Recently，increasingefortsLater，theenantios
6、electivityofthistransformationWaShadconcentratedonthedevelopmentofmethodsforfurtherimprovedupto>99％eebytheuseofsimilarthesynthesisofchiral屆-aminophosphonates?．Cata-butmorepowerfulcatalystsbyDoherty[。]andChavez[¨]lyticasymmetricreductionoffl-enaminophosphonates．ToOUrbestknowled
7、ge，sofartherehadconstitutedamoststraightforwardapproachtoenanti—beennometal-freeorganocatalyticmethodsreportedomericallypure·aminophosphonates，which，howev-intheliteraturethatcouldellableenantiose1ectivere．er，hadonlygaveraresuccessfulexamples．In2008，ductionoffl—enaminophosphona
8、tesfortheproduction收稿日期：2012-05-08；修回侶期：2012-06-07基金項(xiàng)目：國(guó)家自然科學(xué)
