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《新型二茂鐵類手性膦—亞磺酰胺配體的合成及其在不對稱催化反應(yīng)中的應(yīng)用》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、分類號R914UDC615密級公開新型二茂鐵類手性膦-亞磺酰胺配體的合成及其在不對稱催化反應(yīng)中的應(yīng)用馬江微培養(yǎng)類別全日制學(xué)位類型專業(yè)學(xué)位一級學(xué)科(專業(yè)類)藥學(xué)二級學(xué)科(專業(yè))藥物研發(fā)與評價研究方向不對稱催化合成指導(dǎo)教師姜茹教授培養(yǎng)單位藥學(xué)系藥物化學(xué)教研室二O一五年五月第四軍醫(yī)大學(xué)碩士學(xué)位論文目錄縮略語表·······························································································5中文摘要············································
2、···················································7英文摘要·······························································································9前言·································································································11文獻回顧·······································
3、·······················································13正文······························································································35第一部分新型手性膦-亞磺酰胺二茂鐵配體的設(shè)計合成·······························351.1配體的設(shè)計············································································
4、··351.2配體的合成··············································································351.2.1中間81的合成····································································361.2.2中間體82的合成·································································361.2.3中間體83的合成·····························
5、····································371.2.4手性膦-亞磺酰胺配體（L1-L7）的制備······································371.3結(jié)論·······················································································38第二部分新型手性配體在不對稱烯丙基取代反應(yīng)中的催化活性研究··············392.1不對稱烯丙基取代反應(yīng)·········································
6、·······················392.1.1手性配體的篩選····································································402.1.2溶劑篩選·············································································412.1.3堿、添加劑和反應(yīng)溫度對AAA反應(yīng)的影響································422.1.4AAA反應(yīng)的底物擴展····························
7、································432.2結(jié)論························································································46第三部分新型手性配體在金屬銠催化的不對稱芳基化反應(yīng)中的催化活性研究·473.1銠催化的不對稱芳基化反應(yīng)············································
