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1、534中國(guó)臨床研究2012年6月第25卷第6期ChineseJournalofClinicalResearch，June2012，Vo1.25，No.6·論著·血清降鈣素原對(duì)骨折術(shù)后感染的診斷價(jià)值紀(jì)強(qiáng)李穎韓禮綱【摘要】目的探討在骨折術(shù)后感染中血清降鈣素原(PCT)水平檢測(cè)的診斷價(jià)值。方法2008年9月至2011年9月骨折術(shù)后感染患者30例為感染組，同期未發(fā)生感染者30例為非感染組。檢測(cè)2組血清PCT和C-反應(yīng)蛋白(CRP)的水平，對(duì)比兩指標(biāo)在診斷骨折術(shù)后感染診斷中的敏感度和特異度。結(jié)果PCT水平在感染組明顯高于非感染組〔(8．68±2.73)vs(0.18±0.09)ng/ml，P＜0
2、.01〕。PCT和CRP對(duì)骨折術(shù)后并發(fā)感染診斷的敏感度分別是93.3%、100.0%，特異度分別是90．0%、10．0%，陽(yáng)性預(yù)測(cè)值分別為90．3%、52．6%，陰性預(yù)測(cè)值分別為93．1%、100.0%。PCT對(duì)骨折術(shù)后并發(fā)感染的特異度和陽(yáng)性預(yù)測(cè)值高于CRP(P均＜0.01)。結(jié)論P(yáng)CT可用于診斷骨折術(shù)后感染，不易受創(chuàng)傷及手術(shù)因素干擾，具有較高敏感度和特異度?！娟P(guān)鍵詞】骨折;感染;降鈣素原;C-反應(yīng)蛋白;診斷中圖分類號(hào):R683R63文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):1674－8182(2012)06－0534－02*Thediagnosticvalueofprocalcitoninforpos
3、toperativeinfectioninpatientswithbonefractureJIQiang，LI*Ying，HANLi-gang．DepartmentofSpineSurgery，SecondAffiliatedHospital，QingdaoUniversityMedicalCollege，Qingdao266042，China【Abstract】ObjectiveToexplorethediagnosticvalueofserumprocalcitonin(PCT)forpostoperativeinfectioninpa-tientswithbonefracture
4、．MethodsEligible30patientswithbonefracturecomplicatedpostoperativeinfectionfromSeptember2008toSeptember2011wereservedasinfectiongroup，and30caseswithoutcomplicationsofpostoperativeinfectioninthesametimewereselectedasno-infectiongroup．ThelevelsofserumPCTandC-reactiveprotein(CRP)wasmeasured，andthei
5、rsensibilityandspecificityfordiagnosingpostoperativeinfectioninpatientswithbonefracturewerecompared．ResultsPCTlevelininfectiongroupwassignificantlyhigherthanthatinno-infectiongroup〔(8．68±2．73)vs(0．18±0．09)ng/ml，P＜0.01〕．ThesensibilitiesofPCTandCRPfordiagnosingpostoperativeinfectionofpatientswithb
6、onefracturewere93．3%and100．0%respectively，andthespecificitieswere90．0%and10．0%respectively．ThepositivepredictivevaluesofPCTandCRPfordiagnosingpostoperativeinfectionofpatientswithbonefracturewere90．3%and52．6%respectively，andtheirnegativepredictivevalueswere93．1%and100．0%，respectively．Thespecifici
7、tyandthepositivepredictivevalueofPCTfordiagnosingpostoperativeinfectionofpatientswithbonefracturewereobviouslybetterthanthoseofCRP(allP＜0.01)．Con-clusionsPCTcanbeusedindiagnosingpostoperativeinfectionoffracture，becauseitisno
