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1、1610GuangxiMedwaZJournaf，Dec．2012，Vo1．34，No．12老年人冠心病與缺血性腦卒中載脂蛋白E基因多態(tài)性對(duì)比研究▲呂澤峰龐國(guó)防胡才友呂淵(1廣東省惠州市第四人民醫(yī)院內(nèi)科，惠州市516055，E—mail：lvzf69@163．com；2廣西壯族自治區(qū)江濱醫(yī)院神經(jīng)內(nèi)3科，南寧市530021)【摘要】目的探討老年人冠心病與缺血性腦卒中載脂蛋白E(ApoE)基因分布及其與臨床類(lèi)型的關(guān)系。方法>60歲的冠心病患者68例(急性心肌梗死38例、不穩(wěn)定型心絞痛30例)和>60歲的缺血性腦卒中患者61例(腦梗死30例、短暫性腦缺血發(fā)作31例)，健康人156例為對(duì)照組，采
2、用PCR進(jìn)行ApoE基因分型。結(jié)果3組ApoE基因型分布及等位基因頻率比較，差異有統(tǒng)計(jì)學(xué)意義(P<0．05)；冠心痛組及缺血性腦卒中組各基因型及等位基因頻率比較，差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0．05)；正常對(duì)照組ApoEa3為優(yōu)勢(shì)基因，冠心病組及缺血性腦卒中組ApoEs,4基因頻率及等位基因頻率均較對(duì)照組高(P<0．05)；急性心肌梗死、不穩(wěn)定型心絞痛、腦梗死、短暫性腦缺血發(fā)作4組ApoE~-,4基因陽(yáng)性率比較，差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0．05)。結(jié)論ApoEa4(+)是老年人冠心病與缺血性腦卒中共同危險(xiǎn)因素，其機(jī)理可能與ApoEs4陽(yáng)性促進(jìn)動(dòng)脈粥樣硬化有關(guān)?！娟P(guān)鍵詞】缺血性腦卒中；冠心??；載脂
3、蛋白E；基因多態(tài)性【中圖分類(lèi)號(hào)】R541．4；R743【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】0253-4304(2012)12—1610-03ComparativeStudyonApofipoproteinEGenePolymorphismsbetweenCoronaryHeartDiseaseandlschemicStrokeintheElderlyLVZe~ng，PANGGuo乒。，HUCai-you，LVYuan(DepartmentofInternalMedicine，theFourthPeopleSHospitalofHuizhouCity，Huizhou516005，China；2De
4、partmentofNeurology，JiangbinHospital，GuangxiZhuangAutonomousRegion，Nanning530021，China)【Abstract】ObjectiveToexplorethedistributionofapolipoproteinE(ApoE)geneanditsclinicaltypesintheelderlywitllischemicstrokeorcoronaryheartdisease(CHD)．MethodsSixtyeightCHDpatientsaged60yearsandover(CHDgroup)includ
5、ing38casesofacutemyocardialinfarctionand30casesofunstableanginapectoris，andsixtyonepatientswithischemicstroke(IS)aged60yearsandover(ISgroup)including30ca$~sofcerebralinfarctionand31casesoftransientischemicattackwereenrolledinthestudy，156normalinthecontrolgroup．PCRwasappliedtoclassifyApoEgene．Resu
6、ltsThedistributionofApoEgeneandtheallelefrequencyshowedsignificantdiferenceamongthreegroups(P<0．05)，butdidnotshowedsignificantdiferencebetweenCHDgroupandISgroup(P>0．05)．ApoEs3wasthedominategeneinthecontrolgroup，thefrequenciesofApoE~4geneandallelewerehigherintheCHDgroupandISgroupthanthoseinthecont
7、rolgroup(P<0．05)．TherewasnosignificantdiferenceinpositiverateofApoE~4geneamongfourgroupsincludingpatientswitllacutemyocardialinfarction，unstableanginapectoris，cerebralinfarctionandtransientischemicattack(P>0．05)．Conclu
