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1、墮蘭竺塑!岍】【lle.comProgressinModernBiomedicineVoLI4NO.21JUL2014.4067.doi:10.132418.cnki.pmb.2014.21.017不同化療方案對(duì)晚期非小細(xì)胞肺癌患者骨髓抑制及免疫功能的影響蘇同義朱鐵年高冬梅張怡梅趙青蘭(白求恩國(guó)際和平醫(yī)院腫瘤科河北石家莊050082)摘要目的:探討不同化療方案對(duì)晚期非小細(xì)胞肺癌患者骨髓抑制及免疫功能的影響。方法:選取2011年1月至2013年12月收治的130例晚期非小細(xì)胞肺癌患者,按照知情同意原則隨
2、機(jī)分為三組:NP(長(zhǎng)春瑞濱+順鉑)組45例、GP(吉西他濱+順鉑1組43例、TP(紫杉醇+順鉑)組42例,分別于化療前及化療2個(gè)周期后檢測(cè)患者的骨髓抑制及免疫水平。結(jié)果:三種化療方案進(jìn)行治療后骨髓抑制水平由高到低排列為GP組、TP組、NP組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);GP組血小板減少發(fā)生率高于其他兩組.TP組白細(xì)胞下降發(fā)生率高于其他兩組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);三組患者化療后的免疫功能指標(biāo)均較化療前低,差異有統(tǒng)計(jì)學(xué)意義(P<0.05o三種化療方案進(jìn)行治療后免疫功能抑制水平由高到低排列
3、為GP組、TP組、NP組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05o結(jié)論:GP組患者血小板下降更明顯,TP組白細(xì)胞下降更為明顯,NP組對(duì)骨髓抑制及免疫功能抑制較緩和,更適于老年人,因此臨床選擇化療方案時(shí)要綜合考慮患者骨髓狀況、免疫功能情況及年齡等。關(guān)糊:晚期非小細(xì)胞肺癌;順鉑;長(zhǎng)春瑞濱;吉西他濱;紫杉醇中圖分類號(hào):R734.2文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):1673.6273(2014)21.4067.04EffectOnBoneMalHowSuppressionandImmuneFunctionOfDif.feren
4、tChemotherapyRegimensinPatientswithAdvancednonSmallCellLungCancersuTong-yi,ZHUTie-nian,GAODong-mei,ZHANGYi-mei,ZHAOQing-lan(Depat~entofoncology,bethuneinternationalpeacehospimLShijiazhuang,Hebei,050082,ChinABSTRACTObjective:Tostudytheefectonbonemarowsup
5、pressionandimmunefunctionofdiferentchemotherapyregimensinadvancednonsmallcelllungcancerpatient.Methods:130casesofadvancednonsmallcelllungcancerpatientstreatedinourhospitalfromJanuary2011toDecember2013wereselectedandrandomlydividedinto3groupsaccordingtot
6、heprincipleofinformedconsent:NPgroup(ChangchunvinorelbineplusDDP,n=45),GPgroup(GemcitabineplusDDP,n=43)andTPgroup(DocetaxelplusDDP,n=42).Bonemarowsuppressionandimmunelevelweredetectedbeforethechemotherapyandafter2cyclesofthechemotherapyrespectively.Resu
7、lts:Theafter-treatmentbonemarrowsuppressionlevelsofthethreechemotherapyregimensrankedfromhightolowasGPgroup,TPgroupandNPgroup,andthediferencewasstatisticallysignificant(P<0.05).ThethrombocytopeniarateofGPgroupwashigherthantheothertwogroups,theleucopenia
8、rateofTPgroupwashigherthantheothertwogroups,thediferencewasstatisticallysignificant(P<0.05).Theimunefunctionindicatorsofthreegroupsaftertreatmentweredecreasedthanthosebeforethetreatment,thediferencewasstatisticallysignificantfP<0