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1、慢性乙型肝炎患者檢測乙型肝炎病毒大蛋白的臨床意義［摘要］目的：探討乙型肝炎患者檢測乙型肝炎病毒大蛋白(HBV-largeprotein,HBV-LP)的臨床意義。方法：選擇120例慢性乙型肝炎患者，采用免疫熒光法檢測乙型肝炎病毒基因(HBvirus-DNA,HBV-DNA),酶聯(lián)免疫吸附法檢測HBV-LP和乙型肝炎表面抗原(HBVeantigen,HBeAg),比較HBV-DNA、HBV-LPRHBeAg的檢岀率，比較HBeAg陰性患者HBV-LP、HBV-DNA血清學檢出率，分析HBV-DNA、HBV-LP及HBeAg的
2、相關關系。結果：HBV-LP檢出率為87.50%,顯著高于HBV-DNA(70.00%)(x2=10.9804,P<0.01)和HBeAg檢出率(38.33%)(x2=62.1653,P<0.01)；HBeAg陰性患者HBV-LP陽性檢出率為82.43%,顯著高于HBV-DNA檢出率(44.59%)(x2=22.8589,P<0.01)；相關性檢驗顯示HBV-LP與HBV-DNA及HBeAg之間存在正相關關系(rs=0.573,P［關鍵詞］乙型肝炎病毒；大蛋白；臨床價值［中圖分類號］R446.62［文獻標識碼］B［文章編號
3、］1673-7210(2011)12(a)-099-02ClinicalsignificaneeofdetectingHBV-LPonpatientswithchronicitytypeBhepatitisZHAOXiaDepartmentofClinicalLaboratory,RedCrossHospitalinNanjingCity,JiangsuProvinee,Nanjing210001,China[Abstract]Objective:Toinvestigatetheclinicalsignificaneeof
4、detectingHBV-largeprotein(HBV?LP)onpatientswithchronicitytypeBhepatitis.Methods:120casesofpatientswithchronicitytypeBhepatitiswereselected,HBV-DNAweredetectedbyimmunofluorescence,HBV-LPandHBVeantigen(HBeAg)weredetectedbyenzymelinkedimmunosorbentassay,thedetectionr
5、ateofHBV-DNA,HBV-LPandHBeAgwerecompared,thedetectionrateofHBV-LPandHBV-DNAwerecomparedinpatientswithnegativeHBeAg,correlationofHBV-LPwithHBeAgandHBV-DNAwasanalyzed.Results:ThedetectionrateofHBV-LP(87.50%)washigherthanHBV-DNA(70.00%)(x2=10.9804,P<0.01)andHbeAg(38.3
6、3%)(x2=62.1653,P<0.01),thedetectionrateofHBV-LP(82.43%)washigherthanthatofHBV-DNA(44.59%)inpatientswithnegativeHBeAg(x2=22.8589,P<0.01),correlationtestingshowntherewerepositivecorrelationbetweenHBV-LPwithHBV-DNAandHBeAg(rs=0.573,P2.2HBeAg陰性患者中HBV-LP與HBV-DNA檢測結果74例
7、HBeAg陰性的慢性乙型肝炎患者中，HBV-LP陽性率為82.43%(61/74),HBV-DNA陽性率為44.59%(33/74),HBV-LP陽性率顯著高于HBV-DNA陽性率(P
