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1、華西藥學(xué)雜志W(wǎng)CJ·PS2005,20(5):385~387"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""肝蘇緩釋膠囊精制工藝中大孔吸附樹脂型號(hào)的篩選謝興亮,楊明!,邱雪蘭,許潤(rùn)春,馬鴻雁(成都中醫(yī)藥大學(xué),四川成都6l0075)摘要:目的篩選適合分離純化趕黃草提取物的最佳大孔吸附樹脂型號(hào)。方法以槲皮素吸附量、解吸率、吸附速率及解吸速率為指標(biāo),對(duì)Dl40、Dl4l、D3520、AB-8、Dl0l、DM-l30、NKA-9、S-8等8種大孔吸附樹脂的性能進(jìn)行
2、比較。結(jié)果8種大孔吸附樹脂對(duì)槲皮素的靜態(tài)吸附量順序?yàn)椋篋l40>Dl4l>D3520>AB-8>Dl0l>DM-l30>NKA-9>S-8,解吸率順序?yàn)椋篋l40>Dl4l>S-8>AB-8>NKA-9>D3520>DM-l30>Dl0l。其中Dl40、Dl4l對(duì)槲皮素的吸附量分別為9.72、8.76m·-l,解吸率分別為88.5%、84.3%;吸附速率和解吸速率比較結(jié)果表明,Dl40型樹脂在加入藥液后約5h吸附達(dá)到平衡,在加g入解吸劑后l.5h解吸完全,其吸附、解吸速率最快。結(jié)論在8種樹脂中,Dl40的吸附與解吸效果最佳。關(guān)鍵詞:肝蘇緩釋
3、膠囊;精制工藝;吸附樹脂;型號(hào)篩選;槲皮素;吸附;解吸中圖分類號(hào):R9l7,9l2文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):l006-0l03(2005)05-0385-03SelectionofmacroreticularresinintherefinetechnologyofGansusustained-releasecapsuleXIEXing-Iiang,YANGMing!,OIUXue-Ian,XURun-chun,MAHong-yan(ChengduUniuersityofTCM,Chengdu6l0075,China)Abstract:OBJE
4、CTIVEToseIectthebesttypeofmacroreticuIarresininrefiningtheextractsofPenthorumChinesepursh.METHODSEightmacroreticuIarresigns-Dl40,Dl4l,D3520,AB-8,Dl0l,DM-l30,NKA-9,S-8wereestimated.RESULTSTheadsorptionamountofgucertinwasDl40>Dl4l>D3520>AB-8>Dl0l>DM-l30>NKA-9>S-8,whiIetherat
5、ioofreverseadsorptionwasDl40-l,Dl4lwas8.76>Dl4l>S-8>AB-8>NKA-9>D3520>DM-l30>Dl0l,inwhichtheadsorptionamountofDl40was9.72mg·g-l,andthereverseadsorptionofDl40andDl4lwere88.5%and84.3%,respectiveIy.Itwasfoundthatabout5hoursafterputtingthemg·gmedicineIiguidintoDl40,theadsorptio
6、namountreachedthemaximumandaboutl.5hoursafterputting50%ethanoIintoDl40,thereverseadsorptionamountreachedthemaximum.CONCLUSIONAmongtheeightmacroreticuIarresins,macroreticuIarresinDl40wasthebestone.eywords:Gansusustained-reIeasecapsuIe;RefinetechnoIogy;MacroreticuIarresin;Ty
7、peseIection;Oucertin;Adsorption;Reverseadsorp-tionCLCnumber:R9l7,R9l2Documentcode:AArticleID:l006-0l03(2005)05-0385-03肝蘇緩釋膠囊是以趕黃草為原料制備的緩釋制SHA-C型恒溫震蕩器(常州國(guó)華電器有限公司)。劑,是在肝蘇顆粒的基礎(chǔ)上進(jìn)行的二次開發(fā)。趕黃草AB-8、S-8、NKA-9、D3520型大孔吸附樹脂(南大為虎耳草科植物扯根菜(PenthorumChinesepursh),所化工廠);Dl40、Dl4l型大孔吸附樹脂(成
8、都晨光化含以槲皮素為代表的黃酮類成分具有清除自由基、工研究院);DM-l30型大孔吸附樹脂(山東魯抗醫(yī)[l]抗氧化、抗病毒等作用。藥股份有限公司樹脂分廠);槲皮素對(duì)照品(中國(guó)生大