中藥癌熱寧栓劑治療癌性發(fā)熱30例臨床觀察

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1、維普資訊http://www.cqvip.com·318·醫(yī)結(jié)金盤圭E月第28卷第4期CJITWM，April2008．v01．28．N0．4中藥癌熱寧栓劑治療癌性發(fā)熱3O例臨床觀察賈英杰李小江張瑩孫一予陳軍張?zhí)N超摘要目的觀察中藥癌熱寧栓劑治療癌性發(fā)熱的臨床療效。方法采用隨機對照方法將54例癌性發(fā)熱患者分成觀察組(30例)和對照組(24例)，觀察組予中藥癌熱寧栓劑納肛，對照組以消炎痛栓劑納肛。7天為1個療程。停藥7天后，用放射免疫法檢測血清腫瘤壞死因子．僅(TNF．僅)、白細胞介素．1B(IL．1B)水平；檢查血、尿、便常規(guī)及肝、腎功

2、能；觀察患者治療前后體溫、臨床主癥的變化及不良反應(yīng)。結(jié)果兩組降熱有效率分別為86．7％和66、7％，差異有統(tǒng)計學意義(x=8，06，P<0．05)，觀察組治療后患者血清TNF．僅、IL一1B水平明顯低于對照組(t=7．477、t=3．492，P<0，01)，并且能夠明顯改善患者臨床主要癥狀(t=4．71。P<0．05)，提高患者生活質(zhì)量(x=7．38，P<0、05)，與對照組比較差異均有統(tǒng)計學意義。對外周血象無明顯影響，并未見明顯心、肝、腎功能損害。結(jié)論中藥癌熱寧治療癌性發(fā)熱，退熱作用持久而穩(wěn)定，無明顯不良反應(yīng)，值得臨床使用和推廣。關(guān)

3、鍵詞癌熱寧；栓劑；癌性發(fā)熱ClinicalObservationofAireningSuppositoryinTreatmentof30PatientswithCarcinomaFeverJIAYing．jie，LIXiao—jiang，ZHANGYing，etalDepartmentofOncology，The胍￡AffiliatedHospitalofTianjinUniversityofTraditionalChineseMedicine，Tianjin(300193)AbstractObjectiveToobservethec

4、linicaltherapeuticeffectofAireningSuppository(ARN)oncarcino—mafever．MethodsAdoptingrandomizedanddouble—blindedmethod，54patientswithcarcinomafeverwereran-domlyassignedtotheobservationgroupandthecontrolgroup，whoweretreatedrespectivelywithARNandindom—ethacinsuppositorybyan

5、aladministering，7daysasonetreatmentcourse．Theeffectonbodytemperatureonpa—tientsandsideefectoccurredwereobserved7daysafterdiscontinuationofthemedication，andpatients’serumtumornecrosisfactor僅(TNF一僅)，interleukin一1BweredeterminedbyRIA，routinetestofblood，urineandstool，livera

6、ndrenalfunctionweretestedaswel1．Bodytemperature，changesofclinicalsymptoms，andadversereactionwereobserved．ResultsTheefectiverateoffeverabatingwas86．7％intheobservationgroupand66．7％inthecontrolgroup，showingsignificantdifferencebetweenthem(=8．06，P<0．05)．Aftertreatment，serum

7、levelsofTNF一僅andIL一1Bintheobservationgroupweremuchlowerthanthoseinthecontrolgroup(t=7．477，t=3．492，P<0．01)．Besides，patients’chiefclinicalsymptomsandqualityoflifeweremarkedlyimprovedintheobservationgroup(t=4．71，P<0．05，x=7．38，P<0．05)，allbetterthanthoseinthecontrolgroup(P<0

8、．05)．Noevidentefectonperipheralbloodfigure，orharmfulimpactonheart，liverandkidneyfunctionwasfound．ConclusionAir