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1、現(xiàn)代生物醫(yī)學(xué)進(jìn)展www~hengwuyixue．comProgressinModernBiomedicineVoL12NO．15MAY2012·2839·光照對麻醉大鼠海馬節(jié)律的影響水謝康寧羅二平申廣浩L△田越鄭麗娟湯池閆一力吳小明孫濤劉娟(1第四軍醫(yī)大學(xué)生物醫(yī)學(xué)工程學(xué)院陜西西安710032；2空軍臨潼航空醫(yī)學(xué)訓(xùn)練鑒定中心陜西西安710600)摘要目的：研究光照刺激對麻醉大鼠海馬節(jié)律的影響。方法：對烏拉坦麻醉大鼠，在海馬中植入電極，通過神經(jīng)信號放大器記錄場電位。重復(fù)對大鼠進(jìn)行視覺刺激，刺激10s
2、，并給予20s的恢復(fù)期。與經(jīng)典掐尾實(shí)驗(yàn)進(jìn)行對比。結(jié)果：烏拉坦麻醉大鼠的掐尾實(shí)驗(yàn)?zāi)軌驅(qū)⒑ｑR場電位從”大不規(guī)則波”(LIA)變成theta波。LIA到theta的轉(zhuǎn)變通常只需1s，掐尾結(jié)束后3s后theta返回LIA。光刺激造成了在5-8s后LIA消失，光刺激撤離后4-6sLIA返回，并沒有引發(fā)theta。結(jié)論：本文結(jié)果提示視覺通路與觸覺通路有不同的優(yōu)先級和行為特性。關(guān)鍵闐：大鼠；海馬；節(jié)律；光刺激中圖分類號：Q95．33文獻(xiàn)標(biāo)識碼A文章編號：1673—6273(2012)15—2839．03Eff
3、ectsofLightStimu1ationontheHippocampalRhythm．ofAnaesthetizedRats*XIEKang-ning~,LUOEr-pin~,SHENGuang-haoTIANgue；ZHENGLi-juar／,TANGChi1,YANYi-lf,WUXiao-min~,SUNTao1,L1UJuan(1SchoolofBiomedicalEngineeringBiomedicalEngineering,TheFourthMilitaryMedicalUni
4、versity,Xi'an,710032；2LintongAviationMedicalEvaluationandTrainingCentreofChineseAirForce,Xi'an,710600)ABSTRACTObjective：Toinvestigatetheeffectsoflightstimulationonhippocampalrhythmofanaesthetizedrats．Methods：Theratswereanaesthetizedwithurethaneandimp
5、lantedwithelectrodesinthehippocampus，fromwhichneurallocalfieldpotentials(LFPs)wererecorded．Lightstimulationwereappliedtotheratsrepetitivelywith10sdurationandadditional20sdelayforrecovery，whichwascomparedwiththeclassicaltail-pinchexperiment．Results：Th
6、etail—pinchofurethane—anesthetizeratcouldchangetheLFPsinhippocampusfromlargeirregularactivity(L)intothetawave，whichindicatedthatasensoryinputcouldcausetheanimalbeing’active’．ThetransitionofLIAtothetawaveiswithinls．a(chǎn)ndthatthetawavebacktoLIAisapproxima
7、tely3safterpinch’Sremova1．WefoundthatlightCaneliminateLIAbutnotelicitthemwave，withmuchlongerdelay，5-9sforLIAdisappearingafterlightonsetand4-6sforUA’Sback．Conclusions：Thismaysuggestthatunderurethane-anesthetizedconditionvisualinputislesssensitiveandwi
8、thlowerprioritycomparingwithtactility．Keywords：Rat；Hippocampus；Rhythm；LightstimulationChineseLibraryClassification：Q95-33Documentcode：AArticleI【)：1673—6273r2012)15-2839-03含不同的uA和theta波的組合：輕度麻醉LIA和theta波交替前言出現(xiàn)；中度麻醉場電位主要是LIA，掐尾實(shí)驗(yàn)?zāi)軌蛞餿heta海馬屬于大腦邊緣系統(tǒng)，是哺乳
