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1、1202華麻阱：雜20I3／'1-l0Ji笫33卷10j9jChit·．j、Iiesthe㈨il，O㈨t，ber20I3，Vnl33，N(1_l()·麻醉并發(fā)癥·右美托咪定對(duì)嚴(yán)重燙傷大鼠心肌細(xì)胞凋亡的影響王惠樞徐世元張良成鄭艇鐘毅蔣煥偉【摘要】目的價(jià)“莢托咪定塒蓖燙傷人鼠心肌胞捌I、一的影響方法健成‘l雄忡sI)人鼠18只，體重220～280g，采川隨機(jī)數(shù)法，將分為3i(rl=6)：塒照((：)、燙f，_J鄉(xiāng)I【(B)、燙傷+右莢托咪定30／kg組(f)21【)地火鼠30％體表面燙傷模型，斂傷按t)alklam1公式補(bǔ)液抗休兜治療。I)綁傷即刻版
2、腔剁J天十E咪定30l*g／kg，13紺腹腔注射窬牛鹽水r燙傷12h取屈心卒心肌組織，光學(xué)顯做鏡觀察心J~JL21i織癇結(jié)，J、用FUNH法確定心J】J【細(xì)胞州r：指數(shù)，應(yīng)用WcsIcrnbit，t法檢洲心肌葡萄糖憫蛋h78(GRtr／8)、C／EBP源蚩(CHOt，)發(fā)結(jié)果jC比較，B組和1D組心肌細(xì)胞凋：指數(shù)外高、心肌GRP78及CHOP喪達(dá)卜凋(，<0．05)；B比較，D組心兒兒細(xì)胞捌亡指數(shù)降低、心』tJL(；RP78jCttOl喪達(dá)F洲(P<0．05)，F(xiàn)I心肌壩傷顯，D組心肌病理傷叫顯減輕。結(jié)論打火托瞇r1f通過抑制，1霞燙傷夫鼠內(nèi)質(zhì)啦
3、激介的心肌細(xì)胞捌，發(fā)揮心肌保護(hù)作J1J『【關(guān)鍵詞】托咪啶；燒傷；心?。话艻、EffectofdexmedetomidineonapoptosisinmyocardialcellsinratswithseverescaldWANGIlui—shu．xt
4、Shi—yaall，ZI1A／~(；Liang—cheng，ZItENGTing，ZHONGYi，,IIANGtlaan—wei．Depattmer~to／’Ane,sthe,siolog~，AfiliatedUniontlospital(Fuji(1~rlMedical1／niversit)，F(xiàn)
5、uzhou350001，ChinaCorres1)otzdingauthor：XUShi-)aafl，DepartrttentArz~：sthesiolog)，ZhujiangHospitalo／、Southern．MedicalUrtiver—sit)．，Guangzhou510282，China．Emaif：XUshi)aan355@163．㈣m【Abstract】ObjectiveT¨evaluatethet“。cloldexm((1e
6、omidine(J『1ap【)Iltusisinmyocardial(-el1sitlratswiths
7、everescull】．MethodsEighteenhealthymaleSI)rague—I)awleyrats，weighing220—280g．weH、randomlyTIT—videdinlo3groups(n=6each)usingarandomnum1)eltable：controlgroup(groupC)，seaMgroul'(gloupB)antiseaM+dexmedetonfidine30l*g／kggroup(gn)LlIlD)．l'hiny[)erT：cn[otI}lItolalhoelySLIT['acewassha
8、vedandthenexposedto94℃watertor12s．Ratswereresuscita!edwithisotonicsalineaec(mtingtoParklamImulaim—mediatelyafterburn．ShamburnwasproducedinCgroup．Ingioup1)．theratsreceiw：~ditlraperiloneaIinjectionoldexmedetomidine30／,g／kgimmediatelyafterburn．a(chǎn)nt]theequal'．／ohJ．nleofnorllla]sal
9、inewasinjett1iTIgioupB．Theleftventri(dewasremovedaL12hafterburnto()[)sciwethepathologi(：alchangesofnlyocaidialtissueswithlightmicroscopeandtodetecttheap(’pt()sisinmyocardial(：ells(TUNEIassay)andexpressic)n()fglucose_regulatedpro—tein78(GRP78)andC／EBP—hom()togousprotein(CIIOI)
10、(usingWesternlflnt)．rhan{qotosisindexwascah：ll—luted．Results(]ompare
