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1、現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志第29卷第2期2014年3月JModLabMed,Vo1.29,No.2,Mar.201473血清心肌酶檢測(cè)在新生兒窒息診斷中的臨床意義呂曉莉,蒼金榮,王華,毛學(xué)源,楊娜,羅小峰,康華,任健康(陜西省人民醫(yī)院a.檢驗(yàn)科;b.新生兒科;c.臨檢中心,西安710068)摘要:目的探討心肌酶檢測(cè)在新生兒窒息診斷中的應(yīng)用價(jià)值。方法選取陜西省人民醫(yī)院收治的82例窒息新生兒為研究對(duì)象,根據(jù)Apgar評(píng)分將其分為Apgar4~7分為輕度組59例,Apgar<3分為重度組23例,抽取入院后12h內(nèi)及治療后第3天靜脈血,并選取3O例同期住院無缺氧的新
2、生兒為對(duì)照組,采用日立717O用速率法檢測(cè)血清天門冬氨酸氨基轉(zhuǎn)移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK—MB)、乳酸脫氫酶(LDH)和一羥酸脫氫酶(HBDH)。結(jié)果重度窒息組AST,CK,CK—MB,LDH和HBDH水平(170.1土32.3U/L,1264.5士207.2U/L,214.5土86.1U/L,918.5士239.5U/L和747.3士172.5U/L)高于輕度度窒息組(72.7±2O.9U/L,460.4士I64.1U/L,70.I±26.6U/L,402.7±107.5U/L和349.6士122.1U/L,t值=7.
3、81,15.87,9.95,11.59和10.07,P均<0.01)高于正常組(33.1±11.8U/L,2O1.1士44.8U/L,23.2±6.5U/L,181.2土34.9U/L和198.1±35.4U/L,t值=5.48,4.97,5.46,6.43和3.89,P均<0.01),治療3天后心肌酶水平大幅回落,與治療前比較差異有統(tǒng)計(jì)學(xué)意義(一1.73,P<0.05)。結(jié)論血清心肌酶水平能較及時(shí)地反映窒息新生兒缺氧性心肌損傷的程度,及早測(cè)定其水平變化,對(duì)判斷病情,指導(dǎo)治療有重要臨床意義。關(guān)鍵詞:新生兒窒息;缺氧缺血;心肌酶譜;心肌損傷中圖分類號(hào)
4、:R722.12;R446.112文獻(xiàn)標(biāo)志碼:A文章編號(hào):1671-7414(2014)02-073—03doi:10.3969/J.issn.1671-7414.2014.O2.O22ClinicalSignificanceofSerumMyocardialCnzymeinNewbornswithAsphyxiaLUxiao~li,CANGJin—rong,WANG—Hua,MA0Xue-yuan,YANGNa,LUOXiao—feng,KANGHua,RENJian—kang,(a.DepartmentofClinicalLaboratory;
5、b.DepartmentofPediatrics;c.ClinicalLaboratoryCentre,ShaanxiProvincialPeople’sHospital,Xi’an710068,China)Abstract:ObjectiveToinvestigatethemyocardialenzymeintheclinicalvalueofneonatalasphyxia.MethodsThelevelofserummyocardialenzymeof82casesnewbornswithneonatalasphyxiaand30health
6、ynewbornsweredetectedwithinthefirst12hoursandthethirdday.Theneonatalwithasphyxiaweredividedintotwogroups,thesevereasphyxiagroup(59cases)andmildasphyxiagroup(23cases).ThemyocardialenzymesAST,CK,CK—MB,LDHandHBDHweremeasuredbyHITACHI7170biochemistryanalyzer.ResultsThelevelofAST,C
7、K,CK—MB,LDHandHBDHinseveregroupweresignificantlyhigher(170.1土32.3U/L,1264.5±207.2U/L,214.5_-4-86.1U/L,918.5士239.5U/Land747.3±172.5U/L)thanthemildgroup(72.7±20.9U/L,460.4±164.1U/L,70.1±26.6U/L,402.7±107.5U/Land349.6±122.1U/L,£一7.81,15.87,9.95,11.59and10.07;P8、roup(33.1±11.8U/L,201.1±44.8U/L,23.2土6.5U/L,181.2±34.9U/Land1