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1、1I辱華^}匕泰蠢世界華人消化雜志2014年3月8B;22(7):1015—1021wcjd@wjgnet.cornISSN1009—3079(print)ISSN2219-2859(online)經(jīng)Z縭C刁£j鱗狀細胞癌抗原SCCA1在肝細胞癌中的表達及意義李石磊,高英堂,單士崗,梁增輝,翟道寬,景麗,劉彤,杜智,王毅軍李石磊.天津醫(yī)科大學第三中心臨床學院天津市300170expressionofSCCA1andtheclinicopathological■背舞資料高英堂,梁增輝,翟道寬.景麗.劉彤,
2、杜智,天津市第三中心原發(fā)性肝細胞featuresofHCCwasanalyzed.醫(yī)院天津市肝膽疾病研究所天津市人工細胞重點實驗室癌fhepatocellular天津市300170carcinoma,Hcc)單士崗,王毅軍.天津市第三中心醫(yī)院肝膽外科天津市RESULTS:Immunohistochemistryshowed為臨床常見的惡300170性腫瘤,進展快,thatSCCA1wasundetectablein62HCCs,43李石磊,碩士,主要從事肝膽疾病的研究adjacentnon-cancer
3、oustissues,10cirrhosisliver預(yù)后差.早診斷早天津市衛(wèi)生局攻關(guān)基金資助項目,No.11KG112治療是改善患者作者貢獻分布:本研究的設(shè)計由王毅軍、高英堂、杜智及李石tissuesand5normallivertissues.stemblot預(yù)后的關(guān)鍵.AFP磊完成:樣本的收集、數(shù)據(jù)統(tǒng)計由李石磊、粱增輝、翟道寬、analysisdemonstratedthat5outof6detected是當前虛硪最廣景麗及劉彤完成:實驗操作及文毒的撰寫由李石磊完成:文章的HCCtissuesha
4、dhigherSCCA1expression泛的肝癌血清標修改由高英堂與王毅軍完成.通訊作者:王毅軍,教授,300170,天津市河東區(qū)津塘路83號,天thanpairedadjacentnon—canceroustissues,and志物.但其應(yīng)用一直受到爭議,因津市第三中心醫(yī)院肝膽外科.wangyj@medmailcorn.cnthattheremainingHCCtissueshowedsimilar此,發(fā)現(xiàn)新的肝癌電話:022—84112148傳真:022—24315132收稿日期:2013—10
5、—10修回日期:2013—12—23expressionpatterntoadjacentnon—cancerous診斷標志物一直接受日期:2014—01—10在線出版日期:2014—03—08tissues.Oneoutof3livercirrhosistissueswas是研究的熱點.SCCA1positive.whileSCAA1expressionwasnotdetectedinnormallivertissuesf0/3).UsingExpressionofSCCA1inhumanqRT—PC
6、R,theexpressionofSCCA1wasfoundin29.5%oftheHCCtissuesf18/61),butSCAA1hepatoce¨uIarcarcinomaandexpressionwasnotdetectedinpairedadjacentitsclinicalsignificancenon—cancerous,1ivercirrhosisandnorma1liverShi-LeiLi,Ying-TangGao,Shi—GangShan,tissues(0/61,0/16,an
7、d0/6,respectively).ThereZeng-HuiLiang,Dao-KuanZhai,Li3ing,TongLiu,weresi~aificantdifferencesinthepositiverateZhiDu,Yi-JunWangofSCCA1betweenHCCandpairedadjacentnon-cancerous,livercirrhosistissues(P=0.000,Shi-LeiLi,ThirdCentralClinica1CollegeofTianjinMedi.
8、0.013).AmplificationplotandmeltcurveplotcalUniversity,Tianjin300170.ChinashowedthattheCTandTmvalueswere8.90±Ying—lTangGao,Zeng-HuiLiang,Dao-KuanZhai,Li1.40and87.9℃forG3PDHand34_37±1.74and.1ing,TongLiu,ZhiDu,KeyLaboratoryof