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1、86中藥藥理與臨床2012；28(1)9品立勛，王力偉，李唐棣，等．姜黃素包合物對實驗性糖尿病商脂m量的影n向．微循環(huán)學(xué)雜志，2007；17(1)：12～14疵大鼠血糖和呶脂水平的影響．中國煤炭工業(yè)醫(yī)學(xué)雜志，2011；14(1)：12陳美娟，喻斌，江亞兵，等．桔梗水提醇沉一I：清部分對鏈脲菌索致特95～96尿病大鼠糖耐量影響的研究．中藥藥理與臨床．2010；26(1)：52—55lO徐錦龍，王一奇，徐佳麗，等瑋葉提取物對高Jn【糖大鼠血糖及肝糖l3王元松，李永星．2型糖尿病胰島索抵抗的中醫(yī)研究近況．新中原含的影響．中華中醫(yī)藥學(xué)刊，2010；28(2)：413-415醫(yī)，2002
2、；34(11)：73—7511邵豐，歐陽靜萍，毛先晴．黃芪多糖對遺傳性糖尿病小鼠肝糖原含EfectsofHedysaripolysacchcride-3onmetabolismofglucoseandlipidandpathologicalchangesofpancreatict~sueinexperimentaltype-2diabeticratsLiXiaodong一，F(xiàn)engDemei’ZhaoLianggong4FengShilan，，(SchoolofPharmacy，LanzhouUniversity，Lanzhou730000；GansuAcademyofTCM，
3、Lanzhou730050；TheSecondPeoplegHospitalofGansuProvince．Lanzhou730000；TheSecondClinicalMedicalSchoolofLanzhouUniversity，Lanzhou730000)Objective：Tostudyefectsofhedysafipolysaecheride一3(HPS-3)onmetabolismofglucoseandlipidandpathologicalchangesofpan—creatietissueonexperimentaltype-2diabeticrats．M
4、ethods：Toestablishanexperimentaltype-2diabeticratsmodel，theratswereselectedandseparatedintonormalcontrol，modelgroup，type一2diabeticmodelgroup，HPS-3(50、100、200mg／kg‘d)diferentdosegroupandmet-formin(200ms／kg·d)treatedgroup，randomlyaccordingtoweight．Ratsofallgroupswereadministeredbyintragastrica
5、dministration．Afterrespectivelyadministeredfor5weeks，thecontentsofglucose，theglucosetolerance，lipids(total—cholesterols，triglyeefides，high—densitylipo—proteincholesterol，low-densitylipoproteincholestero1)；livergotfromtheleaveswasusedtomeasul~glycogenbyanthrone—sulfuricacidmethod；pathological
6、changesofpancreatictissuetakenfromtheratswasstainedandobserved．Results：Comparedwiththemodelgroup，HPS一3ofthethreetreatedgroups，especiallythehighdosegroup(200mg／kg·d)couldsignificantlyreducefastingbloodglucoseinexperi—mentaltype一2diabeticratsandglucosein2hafteroralglucoseintolerancetest，whichi
7、ndicatedthattheimpairedglucosetoleranceinratswasimproved．Besidesthat，HPS一3canre~atedyslipidemiainexperimentaltype-2diabeticrats，inhibittotal—cholesterol，triglyeeridesandlow—densitylipoproteincholesterolrisingandhish—densitylipoproteincholesteroldec
