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1、876中華麻醉學雜志2014年々月第34卷第7期ChinJAnesthesiol,July2014,Vo1.34,No.7.·重癥醫(yī)學·苦碟子對力竭運動致大鼠心肌損傷時線粒體轉錄因子A表達的影響韓霜何錕趙亞冬容俊芳【摘要】目的評價苦碟子對力竭運動致大鼠心肌損傷時線粒體轉錄因子A(mtTFA)表達的影響。方法健康雄性Wistar大鼠4O只,體重200~220g,采用隨機數(shù)字表法分為對照組(c組,=8)、力竭運動組(Es組,n=16)和苦碟子組(Is組,n=16)。采用游泳力竭法建立力竭運動致大鼠心肌損傷模型。Is組于腹腔注射苦碟子注射液20g/kg后行力竭運動。Es組
2、及Is組于力竭后6和24h時分別隨機取8只大鼠,采集下腔靜脈血樣后摘取心臟,采用ELISA法檢測血清eTnI濃度,采用Westernblot法檢測心肌mtTFA蛋白表達。結果與c組比較,Es組及Is組力竭后6和24h時血清cTnI濃度升高,心肌mtTFA蛋白表達下調(P<0.05);與Es組比較,Is組力竭后6和24h時血清cTnI濃度降低,心肌mtTFA蛋白表達上調(P<0.05)。結論苦碟子可通過上調心肌mtTFA蛋白表達減輕力竭運動致大鼠心肌損傷?!娟P鍵詞】菊科;運動過度;心肌疾??;線粒體;轉錄因子Effectofixerissonchifoliaonmito
3、chondriaitranscriptionfactorAexpressionfollowingmyocardialinjuryinducedbyexhaustingexerciseinratsHartShuang,HeKun,Zhaod0,舶Junfang.DepartmentofAnesthesiology,HebeiGeneralHospital,Shijiazhuang,050000,HebeiProvince,ChinaCorrespondingauthor:RongJunfang,Email:rjf13291@163.con【Abstract】Objec
4、tiveToevaluatetheefectofixerissonchifoliaonmitochondrialtranscriptionfactorA(mtTFA)expressionfollowingmyocardialinjuryinducedbyexhaustingexerciseinrats.MethodsFortymaleWistarrats,weighing200—220g,wererandomlydividedinto3groupsusingarandomnumbertable:controlgroup(groupC,n=8),exhaustinge
5、xercisegroup(groupES,n=16)andixerissonchifoliagroup(groupIS,n=16).Themodelofmyocardialinjurywasestablishedbyexhaustingswimming.InISgroup,theratsweresubjectedtoexhaustingswimmingafterintraperitonealixerissonchifolia20g/kg.InESandISgroups,8ratswerechosenat6and24hafterexhaustion,andbloods
6、amplesweretakenfromtheinferiorvenacavafordeterminationofsenlmcardiactroponinI(cTnI)concentrationsbyELISA.TheanimalsweresacrificedafterbloodsamplingandmyocardialspecimenswereobtainedformicroscopicexaminationandfordeterminationofmtTFAexpressionbyWesternblot.ResultsComparedwithgroupC,thec
7、oncentrationofselumcTn1wassignificantlyincreased,andtheexpressionofmtTFAinmyocardialtissueswasdown—regulatedat6and24hafterexhaustioninESand:ISgroups.ComparedwithgroupES,theconcentrationofserumcTn1wassignificantlydecreased,andtheexpressionofmtTFAinmyocardialtissueswasup-regulatedat6an