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1、??.。健康導(dǎo)報.醫(yī)學(xué)版2014年第11期19卷字木討㈨降鈣素原、超敏C反應(yīng)蛋白、白細(xì)胞檢測在膿毒癥患兒診療中的的研究分析李玲華尹鳳蘭李英明(1臨沂市蘭陵縣結(jié)核病防治所山東臨沂276000)(2臨沂市婦幼保健院山東臨沂276000)【中圈分類號lR446【文獻(xiàn)標(biāo)識碼】A【文章編號】1632—5281(2014)11【摘要】目的探討血清降鈣素原(PcT)、超敏c反應(yīng)蛋白(hs—CaP)、白細(xì)胞(wac)~在兒童膿毒癥診斷、治療中的臨床意義。方法2014年1月一8月兒科感染忠兒35例。男21例,女14例;年齡1個月一6歲。分為膿毒癥組(18倒)和非膿毒癥組(17例)。膿毒癥組進(jìn)一步分為嚴(yán)重膿毒
2、癥和非嚴(yán)重膿毒癥組。所有患兒于住院24h內(nèi)進(jìn)行降鈣素原(PCT)、C一反應(yīng)蛋白(CRP)、白細(xì)胞(WBC)計(jì)數(shù)、血?dú)夥治龊筒≡瓕W(xué)檢測,并進(jìn)行小兒危重病例評分。結(jié)果膿毒癥紐PET、CRP、WBC水平明顯高于非膿毒癥組(Pa<0.01);嚴(yán)重膿毒癥組PCT水平明顯高于非嚴(yán)重膿毒癥組,但二組CRP和WBC水平無顯著差異。危重病例評分二組閩差異有顯著性。當(dāng)PCT~>2.2g/L時診斷膿毒癥的敏感性、特異性、陽性預(yù)測值、陰性預(yù)測值分別為96.7%、87.5%、87.9%和96.5%,ROC曲線下面積為0.992:當(dāng)CRP~25mg/L時分別為83%、75%、75.8%、82.8%和0.796;當(dāng)WB
3、C≥13.09@109/L時分別為53%、75%、69.6%、64.1%和0.651。62例惠兒PeT水平與危重評分呈顯著負(fù)相關(guān)(r=一0.64,P<0.01)。結(jié)論在鑒別膿毒癥與非膿毒癥時,PeT優(yōu)于WBC和CRP,是敏感的血清學(xué)標(biāo)志物。PCT水平與危重評分呈顯著負(fù)相關(guān),監(jiān)測患兒PCT改變有助于評估膿毒癥嚴(yán)重程度、療效和預(yù)后?!娟P(guān)鍵詞】降鈣素原C一反應(yīng)蛋白膿毒癥Researchandanalysisofprocaldtonin,C—reactiveproteinwhitebloodcelmeasurementinChildrenwithSepsis【Abstract】0bjectiveT
4、oevaluatethevalueofserumprocaleitonin(PCT),C—reactiveprotein(CRP),whitebloodcell(WBC)measurementondiagnosisofsepsisinchildren.MethodsFromApr.toAug.2014,35padenMinotlrpediatricintensivecareunit(PICU)withmeanageof(2.6±1.2)yearsold(range1monthto8years)weredividedintosepsisgroup(S,n=30)andnon—sepsisgr
5、oup(N,n=32)accordingtothe2005definitionforsepsis.Furthermore,thesepsisgroupwasdividedintosevere(SS.n=11)andmild(SM,n:19)groups.Patientsseveritywascheckedaccordingtoadomesticscoringsystem.Within24hoursofhospitalization,scrotaPCT,C—reactiveprotein(CRP),whitebloodcell(WBC),bloodgasandpathogenicmicroo
6、rganismsweremeasured.ResultsLevelsofPCT,CaPandWBCinSgroupweresig-nitleantlyhigherthanthoseinNgroup(Pa(0.01).Nodiferenceswerefoundingenderandagebetweenthetwogroups.WhenPCT~>2.2g/Lwasapphedasoptimalcut—ofvaluesindiagnosingsepsis,itssensitivity,specificity,positivepredictivevalue,negativepredictiveva
7、luewere96.7%,87.5%,87.9%and96.5%,respectively,and舢underreceiveroperatingcharacteristic(Roe)culNewas0,992;whenCRP>_-25mLwasapplied,thevalueswere83%,75%,75.8%,82.8%and0.796,respectively;andwhenWBC≥13.09×109/Lwasapp