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1、食管癌淋巴轉(zhuǎn)移規(guī)律及手術(shù)方式探討上海市胸科醫(yī)院食管癌淋巴轉(zhuǎn)移特點(diǎn)1.淋巴轉(zhuǎn)移先于血路轉(zhuǎn)移解剖基礎(chǔ):黏膜下層豐富淋巴管臨床經(jīng)驗(yàn):早期淋巴轉(zhuǎn)移、頻率隨侵潤(rùn)深度升高侵犯至粘膜下層,淋巴結(jié)轉(zhuǎn)移率即可達(dá)18~33%侵犯至外膜層以后淋巴結(jié)轉(zhuǎn)移率更高達(dá)78~89%Evidence美國(guó)著名臨床中心經(jīng)驗(yàn),Univ.SouthCaliforniaT.R.DeMeester1994.腫瘤浸潤(rùn)程度(pT)淋巴節(jié)轉(zhuǎn)移率(%)T133T267T3以上89Evidence歐洲著名臨床中心經(jīng)驗(yàn),德國(guó)R.Siewert1995.腫瘤浸潤(rùn)深度(pT)淋巴結(jié)轉(zhuǎn)移率(%)T1a(粘膜層)0T1b(粘膜下層)18T2(肌層)77T
2、3(外膜層)83T4(外侵周?chē)鞴伲?6Evidence日本全國(guó)96家醫(yī)院調(diào)查結(jié)果,K.Isono1991.腫瘤浸潤(rùn)深度(pT)區(qū)域淋巴結(jié)轉(zhuǎn)移率(%)粘膜層(Tis)0粘膜固有層(T1a)30粘膜下層(T1b)51.7肌層(T2)67.9外膜層(T3)78外侵周?chē)鞴?T4)83上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果腫瘤浸潤(rùn)深度(pT)pN1頻度(%)pTis-T1a0pT1b45.5%pT250%pT364.5%pT459.1%食管癌淋巴轉(zhuǎn)移特點(diǎn)2.早期、跳躍式的淋巴轉(zhuǎn)移解剖基礎(chǔ):淋巴管的垂直縱向交通比水平方向的淋巴引流更為豐富臨床經(jīng)驗(yàn):Evidence遠(yuǎn)離原發(fā)病灶的跳躍淋巴結(jié)轉(zhuǎn)移(>10%)黏
3、膜下轉(zhuǎn)移(13.5%)KatoH.IntJCancer1992;50:49-52.上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果腫瘤浸潤(rùn)深度(pT)淋巴管侵犯(%)粘膜下轉(zhuǎn)移(%)pTis-T1a00pT1b9.10pT24.84.8pT313.54.3pT44.52.3Total9.73.6食管癌淋巴轉(zhuǎn)移特點(diǎn)黏膜下轉(zhuǎn)移食管癌淋巴轉(zhuǎn)移特點(diǎn)3.淋巴轉(zhuǎn)移途徑胸段食管癌的轉(zhuǎn)移高發(fā)淋巴結(jié)組群為頸胸交界部的喉返神經(jīng)鏈淋巴結(jié)賁門(mén)-胃左動(dòng)脈-腹腔動(dòng)脈鏈淋巴結(jié)以隆突下淋巴結(jié)為中心的食管旁淋巴結(jié)AkiyamaH,etal.AnnSurg1994;220:364-73.KatoH,etal.JSurgOncol1991;48
4、:106-11.AkiyamaH.ColorAtlasofSurgicalAnatomyforEsophagealCancer.1992.上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果原發(fā)腫瘤部位與各區(qū)域淋巴結(jié)轉(zhuǎn)移率(%):腫瘤位置頸淋巴結(jié)縱隔淋巴結(jié)上腹淋巴結(jié)上縱隔中縱隔下縱隔胸上段2533.312.54.212.5胸中段18.924.530.23.824.5胸下段1010102050ShanghaiChestHospital食管癌淋巴轉(zhuǎn)移特點(diǎn)KugeK.JThoracCardiovascSurg2003Thesubmucosallymphaticplexusextendcraniocaudally.Th
5、elymphaticroutestotheregionalnodeoriginatefromtheintermusculararea.Lymphaticcommunicationbetweenthesubmucosaandintermuscularareawasrarelyapparenthistologically.ShanghaiChestHospital食管癌淋巴轉(zhuǎn)移特點(diǎn)SubmucosaMuscularisMucosaTherecurrentnervenodeoftenreceivedamajorsubmucosallymphaticdrainagerouteascendingalon
6、gthethoracicesophagus.MizutaniM.SurgRadiolAnat2006ShanghaiChestHospital食管癌淋巴轉(zhuǎn)移特點(diǎn)SubmucosaMuscularisMucosaFromthemuscularispropria:totheperiesophagealnodesFromthesubmucosa:totheuppermediastinalandtheparacardialnodes上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果2001-2010,247例胸段食管鱗癌性別:M-206,F-41年齡:31-75歲手術(shù)方式:Iovr-Lewis-80,McKeown-
7、167淋巴結(jié)清掃:2F-191,3F-56上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果pT1aN=9027.3上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果pT1bN=1136.4031上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果pT2N=4221.411.931.9上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果pT3N=14138.326.236.4上海市胸科醫(yī)院系統(tǒng)性淋巴結(jié)清掃結(jié)果pT4N=4443.215.9食管癌根治性切除的標(biāo)準(zhǔn)“根