科哲課-生物醫(yī)學(xué)研究倫理問題-PPT幻燈片

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1、ThegoalofBMRtoproducemedicaltreatmentsthatarebothsafeandeffectiveatprovidinggenuinemedicalbenefit2二、以人為受試者的生物醫(yī)學(xué)研究的歷史與教訓(xùn)ThreeinterrelateddimensionsofBMRgoal3一、涉及人的生物醫(yī)學(xué)研究的倫理意義6一、涉及人的生物醫(yī)學(xué)研究的倫理意義threeothersourcesofworryBiasedoutcomesIndustry-sponsoredresearchtendstoha

2、vefavorableoutcomesforthetesteddrugWeakenedstandarddrugsareoftentestedonareyoungerandhealthierpatientsthanthetargetpopulation.controldrugsisoftenadministeredininsufficientdosesorinadequatewaysSuppressedanddelayedpublicationSubstantialnumbersofclinicaltrialsareneve

3、rreportedinprintlongdelaysinthepublicationofresults7一、涉及人的生物醫(yī)學(xué)研究的倫理意義ChoiceofresearchprojectsethicalramificationsBMRMoralFailuresenormousinequalitiesintheglobalallocationoffundspharmaceuticalcompaniesappeartoinventdiseases8一、涉及人的生物醫(yī)學(xué)研究的倫理意義9二、以人為受試者的生物醫(yī)學(xué)研究的歷史與教訓(xùn)en

4、ormousinequalitiesintheglobalallocationoffundstoresearchdifferentdiseases10一、涉及人的生物醫(yī)學(xué)研究的倫理意義chronic,i.e.,notcurable,buttreatabelnotlethalaffectwealthypeoplecurrentresearcheddiseaseshavethefollowingproperties：Socio-economicfailures1.lackofinnovation?themajorityof‘n

5、ew’drugsinthemarketareslightmodificationsofexistingsubstances?theFDArequiresdrugstobetestedonlyrelativetoplacebosSocio-economicfailures2.Explodinghealthcosts.?U.S.patientshavetopayfarmorefortheirdrugsthanconsumersincomparablecountries13謝謝！