肝星狀細(xì)胞在肝癌細(xì)胞惡性行為中的作用及機(jī)制研究

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1、分類號(hào)：R735.7單位代碼：10312密級(jí)：學(xué)號(hào)：20122135博士學(xué)位論文題目：肝星狀細(xì)胞在肝癌細(xì)胞惡性行為中的作用及機(jī)制研究研究生：張廣指導(dǎo)教師：丁義濤教授學(xué)科專業(yè)：外科學(xué)學(xué)院名稱：南京醫(yī)科大學(xué)鼓樓臨床醫(yī)學(xué)院完成時(shí)間：二○一五年四月苗京醫(yī)科大學(xué)博±學(xué)位論文南京醫(yī)科大學(xué)學(xué)位論文原創(chuàng)性聲明本人鄭重聲明，獨(dú)立進(jìn)巧研究工作所：所呈交的論文是本人在導(dǎo)師的指導(dǎo)下取得的成果。除了文中特別加＾＾標(biāo)注引用的內(nèi)容外，本論義不包含任何其他個(gè)人或集體已經(jīng)發(fā)表或撰寫(xiě)的成果作品。對(duì)本文的研究做出重要貢獻(xiàn)的個(gè)人和集體。，均己在文中Ｗ明確方式標(biāo)明本人完全意識(shí)到本聲明的法律后果

2、由本人承擔(dān)。＇作者簽名：雜日期：年月日［導(dǎo)師簽名：日期；年月日學(xué)位論文版權(quán)使用授權(quán)書(shū)本學(xué)位論文作者完全了解學(xué)校有關(guān)保留、使用學(xué)位論文的規(guī)定，同意學(xué)校保留并向國(guó)家有關(guān)部口或機(jī)構(gòu)送交論文的復(fù)印件和電子版，允許論文被查閱和借閱。本人授權(quán)南京醫(yī)科大學(xué)可臥將本學(xué)位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫(kù)進(jìn)行檢索，可Ｗ采用影印、縮印或掃描等復(fù)制手段保存和匯編本學(xué)位訟文。作者簽名：＾日期：年月日Ｉ導(dǎo)師簽名日期：年月日南京醫(yī)科大學(xué)博士學(xué)位論文目錄中文摘要················································

3、········································1英文摘要························································································3第一部分緒論·················································································6第二部分肝星狀細(xì)胞LX2引起HCC細(xì)胞對(duì)Sorafenib耐受的機(jī)制研究1.引言·································

4、····················································222.材料與方法············································································233.結(jié)果·····················································································374.討論·····························································

5、························58第三部分肝星狀細(xì)胞共培養(yǎng)引起HCC細(xì)胞EMT的機(jī)制研究1.前言·····················································································682.材料與方法············································································693.結(jié)果······························································

6、·······················764.討論···················································································104全文總結(jié)·····················································································114綜述······················································································

7、······115附錄：縮略詞表············································································138攻讀博士期間發(fā)表論文情況·····························································140致謝·························································