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1、BasicsofLC/MSPrimerContentsWhyLiquidChromatography/MassSpectrometry?4Instrumentation6IonSources6Electrosprayionization7Atmosphericpressurechemicalionization8Atmosphericpressurephotoionization9MassAnalyzers10Quadrupole10Time-of-flight11Iontrap11Fouriertransform-ioncyclotronres
2、onance(FT-ICR)12Collision-InducedDissociationandMultiple-StageMS13CIDinsingle-stageMS14CIDandmultiple-stageMS14AdaptingLCMethods16Samplepreparation17Ionizationchemistry17CapillaryLC/MSandCE/MS19Applications20MolecularWeightDetermination20Differentiationofsimilaroctapeptides20
3、Determiningthemolecularweightofgreenfluorescentprotein21StructuralDetermination22StructuraldeterminationofginsenosidesusingMSnanalysis22PharmaceuticalApplications24Rapidchromatographyofbenzodiazepines24Detectionofdegradationproductsforsalbutamol24Identificationofbileacidmetab
4、olites25BiochemicalApplications26RapidproteinidentificationusingcapillaryLC/MS/MSanddatabasesearching26ClinicalApplications28High-sensitivitydetectionoftrimipramineandthioridazine28FoodApplications28Identificationofaflatoxinsinfood28DeterminationofvitaminDinpoultryfeedsupplem
5、entsusingMS3303EnvironmentalApplications32Detectionofphenylureaherbicides32Detectionoflowlevelsofcarbarylinfood32CE/MSApplications34AnalysisofpeptidesusingCE/MS/MS34WhyLiquidChromatography/Massspectrometersalsogeneratethree-MassSpectrometry?dimensionaldata.Inadditiontosignals
6、trength,theygeneratemassspectralLiquidchromatographyisafundamentaldatathatcanprovidevaluableinformationseparationtechniqueinthelifesciencesaboutthemolecularweight,structure,andrelatedfieldsofchemistry.Unlikegasidentity,quantity,andpurityofasample.chromatography,whichisunsuita
7、bleforMassspectraldataaddspecificitythatnonvolatileandthermallyfragilemolecules,increasesconfidenceintheresultsofbothliquidchromatographycansafelyqualitativeandquantitativeanalyses.separateaverywiderangeoforganiccompounds,fromsmall-moleculedrugRmetabolitestopeptidesandprotein
8、s.TraditionaldetectorsforCHCHCHNHCOCHliquidchromatography2223CHCHCHO
