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《Microsatellite Instability as a Biomarker for PD-1Blockade微衛(wèi)星不穩(wěn)定性作為PD-1的生物標(biāo)志物 封鎖》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、ReviewClinicalCancerResearchMicrosatelliteInstabilityasaBiomarkerforPD-1Blockade1232,3JonathanC.Dudley,Ming-TsehLin,DungT.Le,andJamesR.EshlemanAbstractInitialresultsbyLeandcolleagues,whichwerepublishedinwithLynchsyndromeorsomatichypermethylationoftheMLH1theJune25,2015issueoftheNe
2、wEnglandJournalofMedicine,promoter.Theresultisacancerwitha10-to100-foldincreaseinreportsigni?cantresponsesofcancerswithmicrosatelliteinsta-mutations,associatedinthecolonwithpoordifferentiation,anbility(MSI)toanti–PD-1inhibitorsinpatientswhofailedintenselymphocyticin?ltrate,andasu
3、periorprognosis.Diag-conventionaltherapy.This?nding?tsintoabroaderbodyofnosticapproacheshaveevolvedsincetheearly1990s,fromresearchassociatingsomatichypermutationandneoepitoperelyingexclusivelyonclinicalcriteriatoincorporatingpathologicformationwithresponsetoimmunotherapy,withthea
4、ddedfeatures,PCR-basedMSItesting,andimmunohistochemistrybene?tofrelyingonasimple,widelyuseddiagnostictest.ThisforlossofMMRcomponentexpression.TumortypescanbereviewsurveysthepathogenesisandprognosticvalueofMSI,groupedintocategoriesbasedonthefrequencyofMSI,fromdiagnosticguidelinesf
5、ordetectingit,andthefrequencyofMSIcolorectal(20%)andendometrial(22%–33%)tocervical(8%)acrosstumors,withthegoalofprovidingareferenceforitsuseasandesophageal(7%)toskinandbreastcancers(0%–2%).abiomarkerforPD-1blockade.MSIusuallyarisesfromeitherIfinitialresultsarevalidated,MSItesting
6、couldhaveanexpandedgermlinemutationsincomponentsofthemismatchrepairroleasatoolinthearmamentariumofprecisionmedicine.(MMR)machinery(MSH2,MSH6,MLH1,PMS2)inpatientsClinCancerRes;22(4);813–20.ó2016AACR.DisclosureofPotentialCon?ictsofInterestNopotentialcon?ictsofinterestweredisclosed.
7、Editor'sDisclosuresThefollowingeditor(s)reportedrelevant?nancialrelationships:J.R.Grandis—None.CMEStaffPlanners'DisclosuresThemembersoftheplanningcommitteehavenorealorapparentcon?ictsofinteresttodisclose.LearningObjectivesUponcompletionofthisactivity,theparticipantshouldhaveabett
8、erunderstandingofthepathogenesisandclini
