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1、EurRespirJ2001;18:965–970Copyright#ERSJournalsLtd2001DOI:10.1183/09031936.01.00093001EuropeanRespiratoryJournalPrintedinUK–allrightsreservedISSN0903-1936Theeffectsofcoronavirusonhumannasalciliatedrespiratoryepithelium#M.A.Chilvers*,M.McKean*,A.Rutman*,B.S.Myint,M.Silverman*,C
2、.O9Callaghan*Theeffectsofcoronavirusonhumannasalciliatedrespiratoryepithelium.M.A.*ChildrensAsthmaCentre,DeptofChilvers,M.McKean,A.Rutman,B.S.Myint,M.Silverman,C.O9Callaghan.#ERSChildHealth,UniversityofLeicester,#JournalsLtd2001.LeicesterRoyalIn?rmary,andDeptABSTRACT:Humancor
3、onavirus(HCoV)accountsfor1530%ofcommoncolds,butofMicrobiologyandImmunology,UniversityofLeicester,Leicester,UK.onlyonecasereporthasdescribedtheeffectofacoronavirusinfection,thatwasasymptomatic,onhumanrespiratoryepithelium.Correspondence:C.O9Callaghan,Theauthorsexaminedtheeffec
4、tsofinfectionwithHCoVonciliarystructureandChildrensAsthmaCentre,DeptoffunctioninhealthyvolunteersinfectedbyintranasalinoculationwithHCoV229E.AChildHealth,UniversityofLeicester,furtherfourvolunteerswereshaminfectedwithultraviolet-inactivatedvirus.Immedi-RobertKilpatrickClinica
5、lSciencesatelybeforeinoculation(day0)and3dayslater(day3),ciliatedepitheliumwasobtainedBuilding,LeicesterRoyalIn?rmary,bybrushingtheinferiornasalturbinate.Ciliarybeatfrequencywasdeterminedand6694,P.O.Box65,LeicesterLE27LX,beatpatternanalysedforevidenceofdyskinesia(0=normal,3=s
6、everelydyskinetic)usingUK.Fax:441162523282digitalhigh-speedvideophotography.Ciliaryultrastructurewasexaminedbytrans-missionelectronmicroscopy.Symptomdiarieswerekeptforthedurationofthestudy.Keywords:CiliaAllsubjectsinoculatedwithHCoV,includingthethreewhodidnotdevelopsymptomsci
7、liarybeatfrequencyofanupperrespiratorytractinfection,haddisruptionoftheirrespiratoryepitheliumcoronavirusonday3.Althoughtherewasnodifferenceinthemeanciliarybeatfrequencybetweenrespiratoryepitheliumday0(11.3Hz(95%con?denceinterval(CI):8.614.0)andday3(9.4Hz(95%CIultrastructure7
8、.211.6)),therewasasigni?cantincrease(pv0.05)intheciliarydyskinesiasc
