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1、NEWSINFOCUSforinfluenzaandtheotherusualsuspectviruses,soAliMohamedZaki,amicrobiolo-gistatthehospital,ranacoronavirustestatthesuggestionofRonFouchier,avirologistatErasmusUniversityMedicalCentreinRotter-COURTESYOFHPAdam,theNetherlands,whohadworkedontheSARSvirus.On20?September,Zakipostedhisr
2、esultsontheProgramforMonitoringEmergingDis-eases(ProMED),anonlinedisease-reportingsystem,confirmingthatthecoronavirustestswerepositive.Aweeklater,Fouchier’sgroup,whichhadreceivedanisolateofthevirusfromZakiinearlyJuly,publishedthepathogen’sgenomesequenceintheGenBankdatabase.Thegenomeconfir
3、medthatthepathogenwasanewcoronavirus,theclosestrelativesofwhicharefoundinbats.TwodaysafterseeingZaki’sProMEDpost,theUKHealthProtectionAgencyreportedthatithadfoundasecondcase:a49-year-oldmanfromQatarwhofellillon3?Septemberwithsimilarsymptoms.HewasadmittedtointensivecareinDohaon7?Septembera
4、ndTheresearchlegacyoftheSARSvirus(pictured)ishelpingscientiststomovequicklyagainstanewthreat.thentransferredtoaLondonhospital,whereheremainsseriouslyill.ComparingafragmentBIOMEDICALRESEARCHofthegenomesequenceofhisviruswiththatofthefirstcaseshowedthatthetwowereidenti-cal.Theviralgenomesequ
5、encealsoenabledanSARSveteransinternationalgroupofresearchers,includingFouchierandDrosten,toquicklydevisediag-nosticteststhatlookforshort,characteristicstretchesofthevirus’sRNA.Thecollaborationtacklecoronaviruscameeasily,saysDrosten:“ThegoodthinghereisthattheseareallfriendsfromtheSARStime.
6、”ExistingSARSresearchprovidesausefultemplateforfurtherinvestigationofthislat-Genomesequenceofnewvirusspeedsuptesting.estcoronavirus,addsDrosten.Scientistswilluseanimalmodelssuchasmice,ferretsandBYDECLANBUTLERpositiontounderstandthelatestvirusandtomacaquestostudythepathogen’svirulenceandde
7、velopcountermeasuressuchasdrugsandhowitspreads,forexample.Theywillalsotestcientistswhohelpedtofightthe2003vaccines,shouldtheyberequired.“WeareallwhetherantiviralsandvaccinesdevelopedsinceSepidemicofSARS(severeacuterespira-collaboratingagain,”saysChristianDrosten,SAR
