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1、NEWSINFOCUSSYNTHETICBIOLOGYOne-stopMATERIALSSilicenecouldbeCONSERVATIONImperfectEDUCATIONMassiveonlineshoppingforgenethenextgraphene—butnotprotectionforAustralia’scoursesbringbigdatatocontrollersp.150yetp.152marinerichesp.155educationresearchp.160fluviruses,mus
2、tevolvetobeabletolatchontoproteinsonthesurfacesofhumancells.Ina1paperpublishedthisweekinNature,StalinRajattheErasmusMedicalCentreinRotterdam,theNetherlands,andalargelyEuropeanteamreportthatspikesonthesurfaceofhCoV-EMCbindtoDPP4,awell-knownreceptorproteinonhuman
3、cells.WhenthebindingsiteforthevirusonDPP4wasblockedusingantibodies,theviruscouldnotinfectcells;conversely,whenDPP4wasexpressedonthesurfaceofnormallynon-susceptiblecells,hCoV-EMCcouldnowinfectthem.ELIZABETHR.FISCHER,ROCKYMOUNTAINLABS/NIAID/NIHTheauthors“unequivo
4、callydemonstratethatDPP4isthereceptor”,saysIanLipkin,arenownedvirushunteratColumbiaUniver-sityinNewYork.Althoughotherreceptorsorco-receptorsmightbeinvolved,theexperi-mentssuggestnoneedtolookfurther,hesays.Theworkseems“solidandimportant”,addsMichaelFarzan,avirol
5、ogistattheScrippsResearchInstitute’scampusinJupiter,Florida,whoadecadeagoledtheteamthatdiscoveredthereceptorusedbytheSARSvirustoenter2humancells.ThereceptorusedbytheSARSvirusisfoundmainlyoncellsdeepinthelungs.ThathelpstoexplainwhythatviruscausedseriousCoronavir
6、ushCoV-EMCisthoughttohaveoriginatedinbats.diseasebutwasrelativelydifficulttocatchortransmitbycoughingorsneezing,notesChris-VIROLOGYtianDrosten,directoroftheInstituteofVirol-ogyattheUniversityofBonnMedicalCentreinGermanyandanauthorofthelatestNatureReceptorfornew
7、paper.DPP4seemstoshowasimilardistribu-tion,hesays,whichsuggeststhatthenewvirusmightbehaveinthesameway.ButStanleyPerlman,acoronaviruscoronavirusfoundresearcherattheUniversityofIowa,IowaCity,andco-authorofarelatedNews&Viewsarticle3alsopublishedinthisweek’sNature,
8、cautionsthatknowledgeofthedistributionofDPP4inVirusmighthavemanyanimalreservoirs.thehumanairwaysislimited.TheresearchersdidclearlyshowthatthereceptorispresentonBYDECLANBUTLE
