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1、中華腫瘤防治雜志2014年4月第21卷第8期CHINJCANCERPREVTREAT,April2014,Vol.21No.8·637·綜述·講座自噬與腫瘤的研究現(xiàn)狀王賁士1,231陳德喜郭洪亮1.山東省腫瘤醫(yī)院外科四病區(qū),山東濟(jì)南2501172.濟(jì)南大學(xué)·山東省醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與生命科學(xué)學(xué)院,山東濟(jì)南2500223.首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院感染科,北京100069【摘要】目的:總結(jié)自噬與腫瘤相關(guān)的研究現(xiàn)狀,以及在腫瘤診斷、治療及預(yù)后中的作用。方法:應(yīng)用PubMed及CNKI全文數(shù)據(jù)庫(kù)檢索系統(tǒng),以“自噬(Autophagy)、自噬小體(Autophagosome)、細(xì)胞
2、凋亡(Apoptosis)、腫瘤(Cancer)”為關(guān)鍵詞,檢索2009-01-2013-03的相關(guān)文獻(xiàn),共421篇英文文獻(xiàn)和54篇中文文獻(xiàn)。納入標(biāo)準(zhǔn):1)自噬的調(diào)控機(jī)制及相關(guān)因子;2)自噬對(duì)機(jī)體細(xì)胞凋亡的影響;3)腫瘤的發(fā)病、治療及預(yù)后與自噬的相關(guān)性。根據(jù)納入標(biāo)準(zhǔn)符合分析的文獻(xiàn)20篇。結(jié)果:自噬是真核細(xì)胞通過降解細(xì)胞質(zhì)內(nèi)自身結(jié)構(gòu)來維持自我平衡的代謝過程,其在維持蛋白代謝平衡及細(xì)胞內(nèi)環(huán)境的穩(wěn)定、清除廢物、結(jié)構(gòu)重建以及細(xì)胞生長(zhǎng)發(fā)育以及凋亡中起重要的作用。結(jié)論:自噬過程受一系列復(fù)雜信號(hào)分子的調(diào)控。調(diào)控機(jī)制的失調(diào)與腫瘤的病理生理過程存在密切聯(lián)系。自噬因?yàn)閷?duì)細(xì)胞凋亡有重要影響而與腫瘤
3、的發(fā)病、治療和預(yù)后密切相關(guān)?!娟P(guān)鍵詞】自噬;自噬小體;細(xì)胞凋亡;腫瘤;綜述文獻(xiàn)中華腫瘤防治雜志,2014,21(8):637-640Researchofautophagyandtumor1,2,CHENDe-xi3,GUOHong-liang1WANGBi-shi1.DepartmentofGeneralSurgeryⅣ,ShandongCancerHospital,Jinan250117,P.R.China2.SchoolofMedicineandLifeSciences,UniversityofJinan-ShandongAcademyofMedicalSciences,
4、Jinan250022,P.R.China3.DepartmentofInfectiousDiseases,BeijingYouanHospital,CapitalMedicalUniversity,Beijing100069,P.R.China[ABSTRACT]OBJECTIVE:Tosumuptherelatedresearchassociationbetweencancerwithautophagyandtheroleofautophagyinthediagnosisandtreatmentofcancer.METHODS:Totally421Englishartic
5、lesand54Chinesearticlesweresearchedby“autophagy,AutophagosomeApoptosis,cancer”askeywordsinPubMedandCNKIdatabasesfromJan.2009toMar.2013.Totally20paperswereselectedandanalyzedaccordingtotheinclusioncriteriaasfollows:themechanismsandrelatedfactorsofautophagyregulation;Functionsofautophagyinapo
6、ptosis;Therelationshipbetweenautophagyandtheincidence,treatmentandprognosisofcancer.RERULTS:Autophagy,whichoccursinalleukaryoticcells,isaprocessofself-balancingthroughdegradatingofcytoplasmicstructure.Itplaysanimportantroleinmaintainingthebal-anceofproteinmetabolismandintracellularstability
7、oftheenvironment,clearingwaste,remodeling,cellgrowth,devel-opmentandapoptosis.CONCLUSTIONS:Theregulationofthisprocessisaffectedbyacomplexseriesofsignalingmole-cules.Theeffectivenessofregulatorymechanismshasclosingcontactwiththeprocessofcancer.Thusitiswid