資源描述:
《章祥蓀-社團(tuán)結(jié)構(gòu)分析ppt》由會(huì)員上傳分享,免費(fèi)在線(xiàn)閱讀,更多相關(guān)內(nèi)容在教育資源-天天文庫(kù)。
1、1章祥蓀復(fù)雜網(wǎng)絡(luò)的社團(tuán)結(jié)構(gòu)分析Communitystructureincomplexnetworkshttp://zhangroup.aporc.org中國(guó)科學(xué)院數(shù)學(xué)與系統(tǒng)科學(xué)研究院全國(guó)復(fù)雜網(wǎng)絡(luò)會(huì)議,蘇州大學(xué),2010,10,17Bio-molecularnetworks(生物分子網(wǎng))許多生物問(wèn)題,特別是人類(lèi)的疾病,在分子層面上都可歸于“systemsproblems”--LeroyHood許多生物問(wèn)題可以表達(dá)成生物分子網(wǎng)絡(luò)(bio-molecularnetworks)的問(wèn)題。生物分子網(wǎng)絡(luò)包括:蛋白質(zhì)相互作用網(wǎng)(proteininte
2、ractionnetworks),新陳代謝網(wǎng)(metabolicnetworks),基因調(diào)控網(wǎng)(generegulatorynetworks),e.t.;他們都有共同的性質(zhì)更為有趣的是,許多這樣的網(wǎng)是“復(fù)雜”網(wǎng)絡(luò)23復(fù)雜網(wǎng)絡(luò)的典型代表:生物分子網(wǎng)絡(luò)之一----蛋白質(zhì)相互作用網(wǎng)(Scale-free)酵母細(xì)胞中的蛋白質(zhì)相互作用網(wǎng)絡(luò)(A.-L.Barabási,NATUREREVIEWSGENETICS,2004)Jeong,2000,Nature包括太古代(Archae),細(xì)菌(Becterium),真核生物(Eukaryote)在內(nèi)的
3、43個(gè)物種的新陳代謝網(wǎng)(Metabolicnetwork)都是Scale-free的。4Protein-proteininteractionnetworksRui-ShengWang,YongWang,Ling-YunWu,Xiang-SunZhang,LuonanChen.Analysisonmulti-domaincooperationforpredictingprotein-proteininteractions.BMCBioinformatics,8:391,2007ShihuaZhang,Xue-MeiNingandXian
4、g-SunZhang.IdentificationoffunctionalmodulesinaPPInetworkbycliquepercolationclustering.Computationalbiologyandchemistry,30(6),445-451,2006.LuonanChen,Ling-YunWu,YongWangandXiang-SunZhang.InferringProteinInteractionsfromExperimentalDatabyAssociationProbabilisticMethod.Pr
5、oteins:Structure,Function,andBioinformatics,Vol.62,pp.833-837,2006.Xiang-SunZhang,Rui-ShengWang,Ling-YunWu,ShihuaZhangandLuonanChen.InferringProtein-ProteinInteractionsbyCombinatorialModels.IFMBEProceedings,Vol.14,2006,183--186,SpringerBerlinHeidelberg.5Metabolicandsign
6、alingnetworksZhenpingLi,Rui-ShengWang,Xiang-SunZhangandLuonanChen.Detectingdrugtargetswithminimumsideeffectsinmetabolicnetworks.IETSystemsBiology,3(6),523-533,2009ZhenpingLi,Rui-ShengWang,Xiang-SunZhang.MassFlowModelandEssentialityofEnzymesinMetabolicNetworks.LectureNot
7、esinOperationsResearch,9,pp.182-190,WorldPublishingCorporation,Lijiang,2008.JinG,ZhouX,WangH,ZhaoH,CuiK,ZhangXS,ChenL,HazenSL,LiK,WongSTTheKnowledge-IntegratedNetworkBiomarkersDiscoveryforMajorAdverseCardiacEvents.JProteomeRes7(9):4013-4021,20086LuonanChen,Rui-ShengWang
8、,Xiang-SunZhang.BiomolecularNetworks:MethodsandApplicationsinSystemsBiology.JohnWiley&Sons,Hoboken,NewJersey.J