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1、STEMCELLSANDPROTEOMICSChineseJournalofCancerResearch18(3).'161—167,2006j6jSTEMCELLSANDPRoTEoMICSZHOUYong-ming周詠明,GUOTian—nan郭天南,HUANGShi—ang黃士昂StemCellCenter,UnionHospital,TongflMedicalCollege,HuazhongUniversityofSciencesandTechnology,Wuhan460022CLCnumber:Q78Documentcode:AAr
2、ticleID:1000-9604(2006)03-0161-07ABSTRACTThedistinctivefeaturesofproteomicsarelarge-scaleandhighthroughput.Thekeytechniquesofproteomicsaretwo-dimensionalgelelectrophoresis,massspectrometryandbioinformatics.Stemcellcandifferentiateintoallkindsofcells,tissuesandorgans.Thereare
3、manyproteinsandcytokinesinvolvedintheprocessofdifferentiation.Applyingproteomicstechniquestotheresearchofthecomplexprocessofstemcelldifferentiationisofgreatimportancetostudythemechanismandapplicationsofstemcelldifferentiation.Keywords:Proteomics;Two-dimensionalgelelectrophor
4、esis;Massspectrometry;Bioinformatics;StemcellWiththeaccomplishmentofthedraftofhumangenomeprojectandthesequencingofseveraldecadesoforganismsandtheadventureofpost-genomics,proteomics,animportantsubjectofpost—genomics,hasbeenappliedinmanyfieldssuchasbiology,oncologyandmedicine.
5、etc.People'sattentionhasgraduallytransferredfromrevealingthegeneticinfornqationtodiscoveringthefunctionsofthegeneticmaterials.Inconsiderationofthelimitednumberofgenesandtherelativestabilityoftheirstructure.itisrealizedthatgenesareonlythecarrierofgeneticinformation,whereaspro
6、teins.theexhibitorandexecutoroflireactivities.arehighlydynamicandcomplicated.Inordertogetanin.depthviewoflifeactivities.moreknowledgeofthedirectexecutorproteinsisrequired.Theproteomeistheexpressedproteincomplementofthegenomeofasingleeelloraspecifiedtissue.Theproteomicsisthes
7、tudyofthecompositionandtransforillationofproteomeontheReceiveddate:Dec.19,2005;Foundationitem:ThisworkAccepteddate:Ju1.23,2006wassupportedbytheNationalOutstandingY0uthFoundationofChina(No.30225038,andtheNationalKeyResearchProjectofChina(No.00CB510103).Authortowhomcorresponde
8、nceshouldbeaddressed.E-mail:shianghuang2O00@yahoo.cornBiography:ZHOUYong-mi
