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1、IL1β511位點和TNFα308位點基因多態(tài)性與陜西漢族非賁門胃癌的關(guān)系作者:賈皚,龔均,厲英超,萇新明,郝志明,董蕾【摘要】目的探討促炎癥因子白細(xì)胞介素(IL)1β基因啟動子區(qū)511位點及腫瘤壞死因子α(TNFα)308位點基因多態(tài)性與陜西漢族非賁門胃癌易感性的關(guān)系。方法用聚合酶鏈反應(yīng)和限制性片段長度多態(tài)性(PCRRFLP)的方法對陜西漢族106例非賁門胃癌及108例非潰瘍性消化不良患者(對照組)進(jìn)行IL1β啟動子的511位點和TNFα的308位點多態(tài)性分析。結(jié)果IL1β基因啟動子511位點基因型CC、CT、TT頻率在胃癌組和對照組分別為12.3%、54.7
2、%、33%和16.7%、50.9%、32.4%,無顯著性差異(P>0.05)。等位基因C、T頻率在胃癌組和對照組分別為39.6%、60.4%和42.1%、57.9%,其基因型頻率和等位基因頻率在胃癌組和對照組比較均無顯著性差異(P>0.05)。TNFα的308位點的基因型GG、GA、AA頻率在胃癌組和對照組分別為90.6%、1.9%、7.5%和84.3%、12.9%、2.8%,等位基因G、A頻率在胃癌組和對照組分別為91.5%、8.5%和85.6%、14.4%,其基因型頻率和等位基因頻率在胃癌組和對照組比較均無顯著性差異(P>0.05)。結(jié)論IL1β啟動子511位點基
3、因多態(tài)性及TNFα308基因多態(tài)性與陜西漢族非賁門胃癌之間未發(fā)現(xiàn)相關(guān)關(guān)系。14【關(guān)鍵詞】白細(xì)胞介素1;腫瘤壞死因子α;基因多態(tài)性;胃癌;漢族ABSTRACT:ObjectiveToinvestigatethecorrelationofthepolymorphismsoftheIL1βpromoterregion511C/Tandtumornecrosisfactorα(TNFα)308G/AgenewiththesusceptibilityofnoncardiacgastriccancerofShaanxiChinesepopulation.MethodsThepolymor
4、phismsintheIL1βpromoterregionandTNFαweredeterminedbyPCRRFLPinaHannationalityofShaanxiChinesepopulation.Totally106casesofnoncardiacgastriccancerand108casesofnonulcerdyspepsiaascontrolsweresubjectedtoIL1βandTNFαgeneanalysis.ResultsIL1βgenotypefrequenciesofCC,CTandTTwere12.3%,54.7%and33%ingastr
5、iccancergroup;16.7%,50.9%,32.4%incontrolgrouprespectively.AllelefrequenciesofCandTwere39.6%,60.4%ingastriccancergroup;42.1%and57.9%incontrolgrouprespectively.TNFα308genotypefrequenciesofGG,GAandAAwere90.6%,1.9%and7.5%ingastriccancergroup;84.3%,12.9%,2.8%incontrolgrouprespectively.Allelefrequencies
6、ofGandAwere91.5%and8.5%ingastriccancergroup;85.6%and14.4%incontrolgrouprespectively.Therewerenosignificantdifferencesintheallelefrequencyandgenotypeof14IL1β511C/TandTNFα308(P>0.05).ConclusionNeitherthe511C/TpolymorphismintheIL1βpromoterregionnorTNFα308genepolymorphismwasassociatedwithsusc
7、eptibilityofnoncardiacgastriccancerinaHannationalityofShaanxiChinesepopulation.KEYWOEDS:interleukin1β;tumornecrosisfactorα;genepolymorphism;gastriccancer;Chinesepopulation 胃癌是人類最常見的惡性腫瘤之一,陜西是胃癌的高發(fā)區(qū)