通痹顆粒對(duì)冠心病心絞痛合并肥胖(痰瘀阻絡(luò)證)患者et及no水平影響臨床的研究

《通痹顆粒對(duì)冠心病心絞痛合并肥胖(痰瘀阻絡(luò)證)患者et及no水平影響臨床的研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫(kù)。

1、中文摘要目的：觀察通痹顆粒對(duì)冠心病心絞痛合并肥胖患者的臨床療效，血漿中內(nèi)皮素（ET）及血清一氧化氮（NO）水平的影響，探討通痹顆粒治療冠心病心絞痛合并肥胖患者的作用機(jī)制。方法：將門診及住院的60例冠心病心絞痛合并肥胖患者，隨機(jī)分為兩組，分別給予常規(guī)西藥治療和常規(guī)西藥基礎(chǔ)上加服通痹顆粒治療。療程為4周，治療前后做心電圖，檢測(cè)血漿中內(nèi)皮素與血清一氧化氮水平。內(nèi)皮素檢測(cè)用放射免疫法，一氧化氮檢測(cè)采用還原酶法。結(jié)果：兩組患者治療后中醫(yī)證候療效優(yōu)于治療前，組間比較顯示治療組優(yōu)于對(duì)照組，具有顯著性差異（P＜0.05）。兩組治療后心絞痛療效及心電圖療效較

2、治療前均有所改善，組間比較兩組治療后無(wú)顯著性差異(P＞0.05)。兩組在硝酸甘油停減率比較上有顯著性差異（P＜0.05），治療組療效優(yōu)于對(duì)照組。兩組患者治療后血漿內(nèi)皮素及血清一氧化氮水平明顯改善，與治療前比較有顯著性差異（P＜0.01）；組間比較顯示治療組優(yōu)于對(duì)照組，具有顯著性差異(P＜0.05)。結(jié)論：通痹顆粒對(duì)冠心病心絞痛合并肥胖患者的臨床療效確切，能顯著降低患者血漿內(nèi)皮素含量，升高血清一氧化氮含量，說(shuō)明本方具有改善血管內(nèi)皮及保護(hù)血管內(nèi)皮的功能，該方還能調(diào)脂、增加冠脈血流量，實(shí)現(xiàn)對(duì)缺血心肌的保護(hù)作用。關(guān)鍵詞：冠心病心絞痛；肥胖；通痹顆粒

3、；內(nèi)皮素；一氧化氮ClinicalresearchoneffectsofplasmaETandNOlevelsofTongbigranulesonCHDanginapectorispatientswithobesityAbstractObjective:observedtheclinicalcurativeeffectandexaminedtheplasmaendothelin(ET)andserumnitricoxide(NO)levelsoftheTraditionalChineseherbTongbigranulesonCHDang

4、inapectorispatientswithobesity,toexplorethemechanismofTongbiGranuleonCHDanginapectorispatientswithobesity.Methods:60CHDanginapectorispatientswithobesity,whocamefromtheoutpatientandinpatientdepartment,weredividedrandomlyintotwogroups:onegroupwastreatedwithconventionalwester

5、nmedicineandanotherwiththeTraditionalChineseherbTongbigranulesaswellasconventionalwesternmedicine.Thetreatmenttimewas4weeks.MadeECGexaminationtothepatientsbeforeandafterthetreatmentanddetectedtheirplasmaETandserumNOlevel.ETbyradioimmunoassayandNOweredetectedbyreductasemeth

6、od.Results:TheefficacyofTCMsyndromeofthetwogroupsaftertreatmentswerebetterthanthosebeforetreatments.groupscomparisonshowedthatthetreatmentgroupthanthecontrolgroup,withsignificantdifference(P<0.05).ThetwogroupsaftertreatmentcomparedwithbeforetreatmentanginapectorisandECGwer

7、eimproved.groupscomparison,thetwogroupsaftertreatmentshowednosignificantdifference(P>0.05).therateofstoporlessofthetwogroupsinnitroglycerin,therewassignificantdifference(P<0.05),treatmentgroupwasmoreeffectivethanthecontrolgroup.Comparedwithbeforetreatment,theplasmaETandse

8、rumnitricoxide(NO)levelsweresignificantlyimprovedafterthetreatment,bothofthemshowedthatth