復方α酮酸配伍低蛋白飲食對長期腹膜透析患者微炎癥的影響及其與營養(yǎng)狀態(tài)關(guān)系的隨機對照研究.doc

《復方α酮酸配伍低蛋白飲食對長期腹膜透析患者微炎癥的影響及其與營養(yǎng)狀態(tài)關(guān)系的隨機對照研究.doc》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學術(shù)論文-天天文庫。

1、復方α酮酸配伍低蛋白飲食對長期腹膜透析患者微炎癥的影響及其與營養(yǎng)狀態(tài)關(guān)系的隨機對照研究作者：諶衛(wèi),郭志勇,吳灝,孫莉靜,蔡莉莉,徐海燕【摘要】觀察復方α酮酸配伍低蛋白飲食對長期持續(xù)性不臥床腹膜透析（continuousambulatoryperitonealdialysis,CAPD）患者血漿炎癥因子水平變化的影響及其與營養(yǎng)狀態(tài)的關(guān)系?！娟P(guān)鍵詞】低蛋白質(zhì)膳食;酮酸類;腹膜透析;炎癥;營養(yǎng)不良　　Objective:Toinvestigatetheeffectsofthecombinationofαketoacidandlowproteindi

2、etonthelevelsofserumcytokinesinpatientsperformingcontinuousambulatoryperitonealdialysis(CAPD)andtoexploretherelationshipbetweeninflammationandmalnutritioninCAPDpatients.　　Methods:EightynineCAPDpatientswererandomizedintothreegroups,and78casescompletedaoneyearfollowupandwithco

3、mpletedata.Therewere31casesinlowproteindietplusαketoacidgroup,26casesinlowproteindietgroupand21casesinroutineproteindietgroup.Thelevelsofserumalbumin(Alb),prealbumin(PA),retinolbindingprotein(RBP),transferrin(TRF),cholesterol(TC),triglycerides(TG),leptin,andtricepsskinfold

4、thickness(TSF),midarmmusclecircumference(MAMC),bodymassindex(BMI)weremeasured.Thechangesofseruminterleukin1α(IL1α),interleukin6(IL6),tumornecrosisfactorα(TNFα)andCreactiveprotein(CRP)werealsodetected.　　Results:Comparedwithlowproteindietgroup,serumlevelsofPA,RBPandTRFwe

5、resignificantlyincreasedbothinlowproteindietplusαketoacidandroutineproteindietgroups(P<0.01),however,therewasnosignificantdifferenceinthelevelsofPA,RBPandTRFbetweenlowproteindietplusαketoacidgroupandroutineproteindietgroup.TherewasanincreasedtendencyinthecontentofAlb,T

6、C,TG,BMI,TSFandMAMC,buttherewerenosignificantdifferences.TheplasmalevelsofIL1α,IL6andTNFαinlowproteindietplusαketoacidgroupweredecreasedascomparedwiththeroutineproteindietgroup,buttherewerenosignificantdifferences.TheplasmalevelofCRPinlowproteindietplusαketoacidgroupwas

7、lowerthanthatin6theroutineproteindietgroup(P<0.01).　　Conclusion:ThecombinationofαketoacidandlowproteindietcanamelioratemalnutritionandmicroinflammationinCAPDpatients.　　Keywords:lowproteindiet;ketoacids;peritonealdialysis;inflammation;malnutrition　　近年來，營養(yǎng)狀態(tài)作為影響透析患者生存質(zhì)量的

8、一個重要指標逐漸受到重視。一方面，透析患者營養(yǎng)不良的發(fā)生發(fā)展主要與體內(nèi)微炎癥狀態(tài)密切相關(guān)［1］，另一方面，營