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1、ThislecturewasconductedduringtheNephrologyUnitGrandGroundbyMedicalStudentrotatedunderNephrologyDivisionunderthesupervisionandadministrationofProf.JamalAlWakeel,HeadofNephrologyUnit,DepartmentofMedicineandDr.AbdulkareemAlSuwaida.NephrologyDivisionisnotresponsibleforthecontentofthe
2、presentationforitisintendedforlearningand/oreducationpurposeonly.AscitesPresentedbyMahaAl-Sulaimani425200716AscitesDerivedfromtheGreekword“askos”,meaningbagorsac.Definedastheaccumulationoffluidintheperitonealcavity.Itisacommonclinicalfinding,withmanyextraperitonealandperitonealca
3、uses,butmostcommonfromlivercirrhosis.PeritonealcavityItisapotentialspacebetweentheparietalperitoneumandvisceralperitoneum,thetwomembranesseparatetheorgansintheabdominalcavityfromtheabdominalwall.Derivedfromthecoelomiccavityoftheembryo.Largestserosalsacinthebodyandsecretesapproxim
4、ately50mloffluidperday.PeritonealfluidItisanormal,lubricatingfluidfoundintheperitonealcavity.Thefluidismostlywaterwithelectrolytes,antibodies,whitebloodcells,albumin,glucoseandotherbiochemicals.Reducethefrictionbetweentheabdominalorgansastheymovearoundduringdigestion.PatientwithA
5、scitesEtiologyofascitesMostCommoncauses(90%ofcases):PortalHTNsecondarytochronicliverdiseases(cirrhosis)Intra-abdominalmalignancyCongestiveHeartFailureMycobacteriumtuberculosisportalhypertensionItisahighbloodpressureintheportalveinanditstributaries(portalvenoussystem).Itisdefineda
6、saportalpressuregradient(thedifferenceinpressurebetweentheportalveinandthehepaticveins)of5?mmHgorgreater.CausesofportalhypertensionIntrahepaticcauses:livercirrhosisandhepaticfibrosis(e.g.duetoWilson'sdisease,hemochromatosis,orcongenitalfibrosis).Prehepaticcauses:portalveinthrombo
7、sisorcongenitalatresia.Posthepaticobstructionoccuratanylevelbetweenliverandrightheart,includinghepaticveinthrombosis,IVCthrombosis,IVCcongenitalmalformation,andconstrictivepericarditis.Cirrhosismostcommoncausesofcirrhosis:Alcoholicliverdiseaseoralcoholichepatitisviralhepatitis(Bo
8、rC)fattyliverdiseaseOthercausesofascites