聯(lián)合檢測CEA、ADA、LDH及血沉對胸腔積液性質(zhì)判斷的臨床意義

《聯(lián)合檢測CEA、ADA、LDH及血沉對胸腔積液性質(zhì)判斷的臨床意義》由會員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、安徽醫(yī)藥AnhuiMedicalandPharmaceuticalJournal2013Feb;17(2)?223?聯(lián)合檢測CEA、ADA、LDH及血沉對胸腔積液性質(zhì)判斷的臨床意義夏靜，閆雪波,劉榮玉(安徽醫(yī)科大學(xué)第一附屬醫(yī)院老年呼吸內(nèi)科，呼吸病研究所，安徽合肥230032)摘要：目的探討聯(lián)合檢測血清癌胚抗原（CEA)、血清及胸水乳酸脫氫酶（LDH)、胸水腺苷脫氨酶（ADA)及血沉對胸腔積液性質(zhì)判斷的臨床意義。方法以安徽醫(yī)科大學(xué)第一附屬醫(yī)院2011年12月至2012年6月89例住院胸腔積液患者為研究對象，其中25例結(jié)核性胸腔積液患者,42例惡性胸腔積液患者,22例炎性胸腔積

2、液患者；采用電化學(xué)發(fā)光免疫分析法測定血清CEA,酶法（L法）測定血清LDH,速率法測定胸水LDH及ADA,魏氏法測定血沉。結(jié)果惡性胸腔積液患者血清CEA含量明顯高于結(jié)核性及炎性胸腔積液患者；胸水及血清LDH含量在結(jié)核性、惡性、炎性胸腔積液患者中比較無顯著性差異，但三者胸水LDH含量均明顯高于正常范圍，結(jié)核性胸腔積液患者胸水與血清LDH比值明顯高于惡性胸腔積液患者；結(jié)核性胸腔積液患者胸水ADA含量明顯高于惡性及炎性胸腔積液患者；炎性胸腔積液患者血沉明顯高于結(jié)核性及惡性胸腔積液患者，結(jié)核性胸腔積液患者血沉明顯高于惡性胸腔積液患者。結(jié)論聯(lián)合檢測胸腔積液患者血清CEA、胸水及血清L

3、DH,胸水ADA及血沉對輔助判斷胸腔積液的性質(zhì)具有重要價(jià)值。關(guān)鍵詞：胸腔積液;CEA;ADA;LDH;血沉Diagnosticvalueofcombinativedetectionofserumcarcinoembryonicantigen(CEA),adenosinedeaminase(ADA),lactatedehydrogenase(LDH)andESRindifferentialdiagnosisofpleuraleffusionXIAJing,YANXue-bo,LIURong-yu(DepartmentofGeriatricRespiratoryMedicine

4、,theFirstAffiliatedHospitalofAnhuiMedicalUniversity,Hefei,Anhui230032,China)Abstract:ObjectiveToestablishthediagnosticvalueofcombinativedetectionofserumCEA,serumandpleuralfluidLDH,pleuralfluidADAandESRindifferentpleuraleffusionpatients.MethodsFromDecember2011toJune2012,89casesofin-patient

5、swithpleuraleffusionintheFirstAffiliatedHospitalofAnhuiMedicalUniversitywerechosen,including25casesoftuberculouseffusion(TE),42patientswithmalignantpleuraleffusion(MPE)and22casesofinflammatorypatientswithpleuraleffusion(IPE).ThelevelsofserumCEAwereexaminedbyelectrochemilumin-escenceimmuno

6、assaymethod,serumLDHbytheenzymatic(Lmethod),pleuralfluidLDHandADAbyratingmethodandESRbyWestergren.ResultsTheserumCEAofmalignantpleuraleffusionpatientsishigherthanthatofTEandIPEpatients;TheserumandpleuralfluidLDHlevelsinTE,MPE,IPEpatientsshowednosignificantdifference,butthethreepleuraleffus

7、ionLDHlevelsweresignificantlyhigherthanthenormalrange,andtheratioofpleuraleffusionandserumLDHinpatientswithTEwassignificantlyhigherthanthatofpatientswithMPE;ThepleuralfluidADAlevelsofTEweresignificantlyhigherthanthoseoftheMPEandIPE;TheIPEpatientsESRlevelsweres