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1、LiDeyiMicrobialInteractionwiththeHostinPeriodontalDiseases1MainPoints:ThevirulencefactorsofperiodontalpathogensTheinteractionofpathogenswiththehostinperiodontaldiseases2Contentsofthislesson:Textbook:P27-32 P150-152Supplementaryreadingmaterial3一.Preface4HealthGingivitisPeriodontitisGingiva
2、lsulcusgingivaAlveolarboneperiodontalmembranecementumperiodontalpocketerythema,edema5ClassificationSystemforPeriodontalDiseases(1999)GingivalDiseases(牙齦病)ChronicPeriodontitis(慢性牙周炎)AggressivePeriodontitis(侵襲性牙周炎)PeriodontitisasaManifestationofSystemicDiseases(反映全身疾病的牙周炎)Necrotizingperiodo
3、ntalDiseases(壞死性牙周病)AbscessesofthePeriodontium(牙周組織膿腫)PeriodontitisAssosiatedwithEndodonticLesions(伴牙髓病變的牙周炎)DevelopmentalorAcquiredDeformitiesandConditions(發(fā)育性或獲得性異常)678910BacteriaPeriodontiumHostVirulenceEcologicBalance(生態(tài)平衡)Response(Defense)PeriodontalHealthIncreaseEcologicDisturbance(
4、生態(tài)失調(diào))DecreasePeriodontalDiseaseDecreaseEcologicModulation(生態(tài)調(diào)整)Increase(Therapy)HealingProcess11二.MicrobiologicAspectsoftheMicrobe-HostInteraction12PeriodontalPathogensConvincingDataExistSignificantEvidence(證據(jù)充分)(中等證據(jù))ActinobacillusactinomycetemcomitansCampylobacterrectus(伴放線放線桿菌Aa)(直腸彎曲菌
5、)PorphyromonasgingivalisEubacteriumnodatum(牙齦卟啉單胞菌Pg)(纏結(jié)優(yōu)桿菌)BacteroidesforsythusFusobacteruimnucleatum(福塞似桿菌Bf)(具核梭桿菌Fn)Prevotellaintermedia(中間普氏菌Pi)Peptostreptocoscusmicros(微小消化鏈球菌Pm)Streptococciintermedius(中間鏈球菌群)Treponemadenticola(牙密螺旋體Td)131.ColonizationandSurvivalinthePeriodontalRegi
6、onattachment(附著)oradhesion,multiplication(繁殖)andgrowth14SelectedBacterialAdhesinsBacterialAdhesinProbableAttachmentSurfaceFimbriae(Av)ToothMembraneprotein(Pg)TissueHeat-sensitiveprotein(Fn)Preexistingplaquemass15162.BacterialInvasion(入侵)of HostTissue1718193.BacterialEvasion(逃避)ofHostDefen
7、seDegradationofspecificantibodyPg(IgA,IgG)InhibitionofIL-8(productionbyEC)PgKillLeukocytes(produceleukotoxin)Aa(neutrophils,monocytes,lymphocytes)20214.MicrobialMechanismsofHostTissueDamage22BacterialEnzymesCapableofDegradingHostTissuesBacterialEnzymeSpeciesCollagen
