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1、大豆苷元對(duì)結(jié)扎大藏冠狀動(dòng)脈所致?lián)p傷的保護(hù)作用作者：葉和楊，胡志蘋(píng)，周莉，黃志華，曾靖【關(guān)鍵詞】大豆ProtectiveeffectofDa.idzEinonmyocardialischemiainjuryinrats【Abstract】AIM：ToobservetheprotectiveeffectofDaidzEInonratswhosebranchofleftanteriordescendingcoronaryarterieswereligated.METHODS：Ratsischemia.injurymode
2、lwasestablishedbyligatingthebranchofleftanteriordescendingcoronaryarteryforadurativecourseof120min.Thirtytwomaleratswererandomlydividedinto4groups：shamoperationgroup,modelgroup，highdose(mg/kg)DaidzeingroupandlowdoseDaidzeingroup.ThetwoDaidzeingroupswereinjecte
3、dwithDaidzeinoflmL/10OgthroughsublinguaIveinlOminbeforeischemiainjuryandsalinewasgiveninshamoperationgroupandmodelgroup.TheleadIIECGwasrecordedbeforemyocardialischemiainjury,15minafterischemiaand30,60,90andl20minafterinjectionwithDaidzein.TheZSTofleadIIECGatea
4、chmomentmentionedabovewasanalyzedandtheJpointandTwaardialischemiamodeluatetheprotectiveheactivityofcreatinephosphokinase(CKgenase(LDH)inserumndialdehyde(MDA)anse(SOD)inmyocardiadtoevaluatetheprotzein.ThemyocardialuredbyTTCstainingofcardiacmusclecellreofECGinac
5、utemyoclwereobservedtoevaeffectofDaidzein.T)andlactatedehydro,thecontentsofmalodsuperoxidedismutaltissuewereobserveectiveeffectofDaidinfarctsizewasmeassinanother24rats(dividedinto3groups：nmg/kggroup,Daidzeyocardialischemiaiamemethods.RESULTSmodelgroup,Daidzeii
6、nmg/kggroup)withmnjuryinducedbythes:Comparedwiththoseinmodelgroup,theaalinfarctiondeclinreaofacutemyocardied,thevalueofZSTreducedandthemaximumvaluesofJpointandTwareofECGdeclinedinthe2Daidzeingroups.TheactivityofLDHandCKinthe2Daidzeingroupswaslowerthanthatinthe
7、modelgroup.ThecontentofSODwassignificantlyhigherandMDAwasmarkedlylowerintheDaidzeingroupsthanthoseinthemodelgroup.A1lthechangesmentionedaboveshowedsomedosedependenteffect.CONCLUSION：Daidzeinhasobviousprotectiveeffectonmyocardiumagainstischemiainjurycausedbylig
8、atingthebranchof1eftanteriordescendingcoronaryartery.【Keywords】Daidzein；myocardialischemia；coronaryarteryligation；serumenzyme；freeradicals【摘要】目的：觀察大豆苷元對(duì)結(jié)扎大鼠左冠狀動(dòng)脈前降支損傷的保護(hù)作用.方法：取32只雄
