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1、廣東藥學(xué)院碩士研究生學(xué)位論文AbstractObjective：Liuweidihuangdecoctionmetabolizedbyphotosyntheticbacteria(LW-PSB)istheuseofphotosyntheticbacteriametabolizedliuweidihuangdecoction.Usingphotosyntheticbacteriabiologicaltransformationfunctiontochangingliuweidihuangtherapeuticmaterialbasis,earlyresearchshowsthat
2、anti-agingeffectofLW-PSBissuperiorofliuweidihuangdecoction.InordertoensurethestabilityofLW-PSB,drugdosereduction,improvepatientcompliancewithmedication,whileonthebasisofmaintainingefficacy,theLW-PSB’salcohol-solublepartoftheextractdevelopintoaTablet,andpreparingthedraftqualitystandard,andpro
3、videthebasisfornewdrugapplication.Methods:1.ThepreparationofLW-PSBResearchgroupofearlyoptimizingphotosyntheticbacterialmetabolismofliuweidihuangdecoctioncanbepreparedofLW-PSB;2.AlcoholprecipitationtechnologyofLW-PSBAnorthogonaltestwasadoptedtooptimizealcoholprecipitationprocess.3.TheLW-PSBof
4、alcoholsolubleportioneffectsonfecundityandlifespanofDrosophilamelanogasterUsingwildtypeDrosophilaDrosophilmelanogasterasexperimentalsubjects,theLW-PSBalcoholsolublepartsexperimentalstudyonfecundityandlifespanofDrosophilamelanogaster.4.TheLW-PSBalcohol-solublepartofTabletpreparationVisittable
5、ttingconditions,coreparticlemassprescriptionandsemi-finishedproducts,optimizingfilmcoatingformulationandprocessconditions.5.Studyonthequalitystandardofalcohol-solublepartoftheTabletofLW-PSBInaccordancewiththePharmacopoeia(2010Edition)relatingtoTabletqualityinspectionoftherelevantprovisions,t
6、heestablishmentofpaeonolbyTLCanddeterminationofpaeonol,totalsugarcontent,improveitsqualitystandard.6.PreliminarystabilitystudiesalcoholsolublepartoftheLW-PSBtabletFilm-coatedtabletsforhightemperature,highhumidity,stronglightirradiationtestVIII廣東藥學(xué)院碩士研究生學(xué)位論文andacceleratedtesting,stabilitykeyc
7、heckprojectstudiedfilm-coatedtablets.Results:1.AlcoholprecipitationtechnologyofLW-PSB.Takeliquidconcentrationsof0.25g/mLbiologicalpreparationsforofliuweidihuangamount,add90%ofethanol,waterandstir,toafinalconcentrationof65%,thetemperatureat25℃alcoho
