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1、中性粒細胞彈性蛋白酶與肝癌轉(zhuǎn)移的關(guān)系研究唐志強通訊作者王燕清上海市奉賢區(qū)中心醫(yī)院上海201400【摘要】目的：探討中性粒細胞彈性蛋白酶與肝癌轉(zhuǎn)移的關(guān)系。方法：30例肝癌患者根據(jù)癌癥轉(zhuǎn)移的部位分兩組，分別是肝癌不轉(zhuǎn)移組和肝轉(zhuǎn)移組。采用ELISA法測定患者組織上清及血清中NE、IL-6和TNF-α水平，并進行NE與IL-6和TNF-α相關(guān)性的分析。結(jié)果：①肝癌患者血清NE的水平明顯高于對照組(p<0.005),肝癌不轉(zhuǎn)移患者NE水平分別與肝癌轉(zhuǎn)移患者的血清中NE的水平進行比較，差異顯著(p<0.005)
2、,在肝癌組織上清中NE的水平在肝癌不轉(zhuǎn)移及肝癌轉(zhuǎn)移間有明顯的差異(p<0.005)IL-6及TNF-α的水平在肝癌不轉(zhuǎn)移及肝癌轉(zhuǎn)移患者間有明顯的差異(p<0.005)。②相關(guān)性的分析結(jié)果顯示，NE與IL-6及TNF-α呈明顯的正相關(guān)(p<0.005)。結(jié)論：肝癌患者其癌癥組織上清及血清中NE的水平與肝癌侵襲轉(zhuǎn)移有關(guān)，提示調(diào)節(jié)NE的水平有可能成為防止肝癌侵襲轉(zhuǎn)移的新思路?！娟P(guān)鍵字】中性粒細胞彈性蛋白酶；肝癌；侵襲轉(zhuǎn)移【中圖分類號】R329.2【文獻標(biāo)識碼】B【文章編號】1674-8999(201
3、5)8-0239-02Studyontherelationshipbetweenneurtophilelastaseandmetastasisofcolorectalcancer【Abstract】Objective:Toexploretherelationshipbetweenneurtophilelastaseandmetastasisofcolorectalcancer.Methods:60casesofcolorectalcancerpatientswasdividedintothreegroupsincludinggroup
4、withoutmetastasisofcolorectalcancer,groupwithcolorectalcancertransferringtoliverandgroupwithcolorectalcancertransferringtolungbasedonthepositionwherecolorectalcancertransfer.Thelevelsofneurtophilelastase(NE),IL-6andTNF-αintexturalsupernatantandserumweredetectedusi
5、ngtheELISAmethod.Also,thecorrelationofNEwithIL-6andTNF-αwasanalyzed.Results:①ThelevelofNEincolorectalcancerwasmarkedlyhigherthanthatincontrol(p<0.005).Also,significantdifferenceswerefoundinthelevelsofNE,IL-6andTNF-αbetweengroupswithandwithoutmetastasisofc
6、olorectalcancer(p<0.005).Howevernosignificantdifferenceswasshowedbetweengroupwithcolorectalcancertransferringtoliverandtolung.②CorrelationanalysisindicatedthatNEdisplayedapositivecorrelationwithIL-6andTNF-α.Conclusion:TheseresultssuggestedthatNEhadrelationshipw
7、ithmetastasisofcolorectalcancer,especiallytumormetastasistolungandliver,implyingthatregulatingthelevelofNEmaybeathreadforpreventingthemetastasisofcolorectalcancer.【Keywords】neurtophilelastase;colorectalcancer;invasionandmetastasis肝癌是消化道最常見的惡性腫瘤，在我國的發(fā)病率呈逐漸上升的趨勢。通過肝癌根治性切除
8、術(shù)在一定范圍內(nèi)能提高患者的生存率，但由于肝癌極易發(fā)生遠處轉(zhuǎn)移，使得癌癥未得到根治而影響療效，進而影響患者的生存率。所以，阻斷肝癌發(fā)生轉(zhuǎn)移的途徑對于提高患者的生存率具有重要的意義［1】。中性粒細胞彈性蛋白酶屬于鋅離子和鈣離
