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1、BiochemistryZhangguangxianPh.Dzhangguangxian@gzhtcm.edu.cnQQ:99811075Tel:13570212885IntroductionWhatistheBiochemistry?Historyanddevelopment?WhatistheBiochemistrydiscussion?BiochemistryandChinesemedicine?BiochemistryDefinition:ThechemistryoflifeThescienceconcernedwiththechemical
2、basisoflifeThescienceconcernedwiththevariousmoleculesthatoccurinlivingcellsandorganismsandwiththeirchemicalreactionAnythingmorethanasuperficialcomprehensionoflife–inallitsdiversemanifestation-demandsaknowledgeofbiochemistryBiochemistryAim:todescribeandexplain,inmolecularterms,a
3、llchemicalprocessesoflivingcellsStructure-functionMetabolismandRegulationHowlifebegan？ThescopeisaswideaslifeitselfBiochemistrySignificance:beessentialtoalllifesciencesasthecommonknowledgeGenetics;Cellbiology;MolecularbiologyPhysiologyandImmunologyPharmacologyandPharmacyToxicolo
4、gy;Pathology;MicrobiologyZoologyandBotanyBiochemistryMedicalstudentswhoacquireasoundknowledgeofbiochemistrywillbeinastrongpositiontodealwithtwocentralconcernsofthehealthsciences:(1)theunderstandingandmaintenanceofhealth(2)theunderstandingandeffectivetreatmentofdiseaseHistoryand
5、development?1903Neuberg首先提出生物化學(xué)概念發(fā)展：靜態(tài)—動態(tài)—機(jī)能生物化學(xué)1953WatsonandCrickDNA雙螺旋結(jié)構(gòu)（分子生物學(xué)）1972Berggeneengineering1976Kan胎前檢驗(yàn)beta-地貧1977Shine克隆了人生長激素抑制基因1982Cech發(fā)現(xiàn)四膜蟲rRNA可自我剪切（Ribozyme）1986MullisPCR技術(shù)1990基因治療進(jìn)入臨床（ADA）2001HGP完成---后基因組學(xué)時(shí)代---蛋白質(zhì)組學(xué)—生物信息學(xué)1903年CarlNeuberg首次提出“生物化學(xué)”Apioneerbioc
6、hemist,CarlNeuberg(1877-1956)spentoverthirtyyearsofhisproductivecareerasaprofessorattheUniversityofBerlin(1903-1937)andasDirectoroftheKaiserWilhelmInstitutesofBiochemistryandExperimentalTherapy.Hisvariedresearchinterestsresultedinimportantcontributionstotheunderstandingoffermen
7、tationprocesses,solubilityandtransportphenomenaincells,thechemistryofcarbohydrates,sugars,enzymes,andaminoacids,andphotochemistry.NeubergwasforcedoutofhispositionaftertheNazirisetopower,andtakingrefugeintheUnitedStates.Forthelastseveralyearsofhislife,heworkedatNewYorkUniversity
8、.1953WatsonandCrickDNA雙螺旋結(jié)構(gòu)Geneengineering動物克隆轉(zhuǎn)基因PCRfr
