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《復(fù)方米槁抗病毒軟膠囊的提取純化工藝分析》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、貴I釘巾仄學(xué)院壩lj學(xué)化論文高比為l：8。進(jìn)行動(dòng)態(tài)沈脫參數(shù)的優(yōu)化。以沈脫液中甘草酸、綠原酸濃度及干膏率為測(cè)評(píng)指標(biāo)，對(duì)水沈用量、沈脫劑濃度、沈脫流速、沈脫劑用量進(jìn)行了單因素考察，繪制甘草酸、綠原酸的沈脫曲線，確定沈脫終點(diǎn)，結(jié)果最優(yōu)沈脫參數(shù)為水沈用量為1BV，沈脫劑濃度為70％乙醇，沈脫劑用量為2．5BV，沈脫流速為2BV·h～。關(guān)鍵詞：甘草酸，綠原酸，醇沉工藝，大孔吸附樹脂，提取，純化Qingrejiedu，wasmainlyusedforviralinfluenza．OnthebasiSoffolkprescriptiontheprescriptionan
2、dtheformulationprocesswasimprovedandtheextractionandpurificationprocessparameterswasoptimized，andfinallygottheintermediateswhoseformulationprocessisavailableandwhosequalityisstable．Pickuptheevaluationindexes：the}IPLCmethodwasemployedinthiSpapertodeterminethecontentofchlorogenicaci
3、dandglycyrrhizicacidintheextract．AmethodologicalsurveyresultsshowthattheanalyticalmethodiSaccurateandstable．Tooptimizeextractionprocess，themainactivecomponentsofthethreeherbsasindicatorswaschosentoinvestigatetheimpactofseparateddecoctionandmixeddecoctiononthecontentofindexcomponen
4、t．Theresultsshowedthatchlorogenicacidcontentinmixeddecoctionishigherthanthatinseparateddecoction，glycyrrhizicacidextractionwasnosigni／’icantchange．Therefore，threeherbswereextractedtotallyinthisexperiment．Second，becauseoftheinstabilityofchlorogenicacidthisexperimentwasdesignedtoinv
5、estegatethedecoctiontimeandthejoinedway．Asaresult，atthelast0．5hofthefirstboilingjoinFlosLonicerae．Thewater—extractingprocessesofthethreeherbswerestudiedbyorthogonalexperimentwiththecontentofeffectivecomponentsandsolid-extractpercentasindex．Extractingtime，extractingtimesandwateramo
6、untwerechosenasfactors，andthreelevelSwereselectedforeveryfactortooptimizetheprocesses．Theultimateextractingprocesses貴m中醫(yī)學(xué)院傾lj學(xué)位論義weredeterminedasfollows：ThreeherbswereextractedwithlO-foldwaterfor2．Ohbydecoction，andrepeatedfor3times．AndjointheFlosLoniceraeatthelast0．5hofthefirstboi
7、ling．Purificationprocedureparameteroptimization：(1)Inthepre—extractionexperimentsalcoholprecipitationandmacroporousresinpurlficationmethodwereemployedtorefinethewaterextracts．Finnalydeterminethepurificationprocessroute：extract—alcoholprecipitationtoremoveimpurity—recoveryof。ethano
8、l—macroporousresinreilining．(2)Op
