自體骨髓干細(xì)胞移植治療失代償期肝硬化的臨床的的研究 (1)

《自體骨髓干細(xì)胞移植治療失代償期肝硬化的臨床的的研究 (1)》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、ClinicalresearchofautologousbonemarrowstemcelltransplantationfortreatmentofdecompensatedincirrhosisMasterdegreecandidate：YueHouSupervisor：Professor‘XiaozhongGuoVice—supervisor：ProfessorXiaozhongGuoMajor：IntemalMedicineAbstractObiective：Tostudytheclinicaleffectofautologousbon

2、emarrowstemcelltransplantationviahepaticarteryintreamtmentofdecompensatedcirrhosis．Methods：Eightypatients、析廿1decompensatedcirrhosiswereincluded．Amongthem,36patientswerefemale，50patientsweremale，theyaged26to75yearsold，meanagewas51士11yearsold，55patientswereposthepatiticcirrhos

3、is，25patientswerealcoholiccirrhosis，1patientwasschistosomiasiscirrhosis，3patientswereautoimmuneliverdisease．a(chǎn)nd2patientsweredrug．inducedlivercirrhosis．Atotalof180"'200mlbonemarrowwasaspiratedfrompostersuperiorspineinasepticconditions．Afterisolationandpurification，thestemcell

4、sweretransplantedintotheliverviahepaticartery．Aftertransplantation,clinicalsymptomsandsigns，laboratorydataandsideeffectswererecordedatthe2，4and8weeks．Results：Aftertransplantationin2,4and8weeks，levelsofalbuminwasincreased(P

5、otransferasewasdecreased(P

6、g／L．TotalbilirubinlevelWasdecreased，butnosignificantdifferencewasfound．Afterstemeelltransplantation，themajorityofclinicalsymptomswereimproved．In86casesoftransplantpatients，serioussideeffectswerenotfound．Conclusion：Aftertransplantationofautologousbonemarrow,theliverfunctionan

7、dgeneralwell—beingofpatientsweresignificantlyimproved．TKsmethodWassafeandeffectiveinthetreatmentofpatientswithdecopensatedcirrhosis．KeyWords：LivercirrhosisAutologousbonemarrowstemcellsTransplantation2自體骨髓干細(xì)胞移植治療失代償期肝硬化的臨床研究碩士生姓名：侯悅指導(dǎo)教師：郭曉鐘教授指導(dǎo)小組：郭曉鐘教授專業(yè)名稱：內(nèi)科學(xué)-^上-·J一刖吾肝硬化是我國一

8、種常見病和多發(fā)病，占內(nèi)科總住院人數(shù)的4．3％"14．2％，發(fā)病高峰年齡在35"-'48歲，男女比例約為3．6"-'8：1，是危害我國人民健康的一大疾患