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《rna干擾sncg基因表達(dá)對乳腺癌mcf-7細(xì)胞的放射敏感性的影響》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、EffectofRNAinterferenceofSNCGexpressionondiosensitivityofbreastcancerMCF．．7cellraaiosensitivityolbreastCancer7ceHs●-AbstractBackgroundBreastcancerisoneofthemostcommonmalignanttunlorofwomen,andthemostcommonandthesecond-leadingcauseofcancerdeathinAmericanwomen．InChina,t
2、heincidenceandmortalityofbreastcancershowsaclearupwardtrend，whichhasaseriouSimpactonwomen’Sphysicalandmentalhealthandeventhreatentheirlives．Thetraditionaltreatmentofbreastcancerincludessurgery，chemotherapyandradiotherapy．Bytheresearch,40％to60％ofbreastcancerpatientsnee
3、dtoacceptradiotherapy．BreastCanCercellshavemoderatesensitivitytoradiationtherapy，however，thesurvivalratehasnotbeenimprovedsignificantly．Therewillbethepossibilityofrecurrenceormetastasis．Inrecentyears，anewideaaboutgene—radiotherapyoftumorisputforwardforthetreatmentoftu
4、mors．Thisstudywillbeanorganiccombinationofgenetherapyandradiotherapy，aimingtoresearchthesensitizationeffectofgenetherapyonbreastcancerradiotherapyandtoexploreitsmechanism．SNCG(gamma-synuclein)wasoriginallyfoundinhumanbreastcancergeneeDNAdatabasestll．Duetothespecificex
5、pressionofSNCGinadvancedbreastcancer,itiscalledbreastcancer-specificgeneI(BCSGI)．SNCGgeneislocalizedonchromosome10q23andencodesasmaller123aminoacidprotein[2]．Studiesshowthatover-expressionofwild-typeSNCGproteininCanCermightbeassociatedwithmalignancy[31．Thus，SNCGexpres
6、sionleadstoover-ridingthemitoticarrestallowingcellstocontinueprogressionthroughthecellcycleresultinginaneuploidy．ThestudyofSNCGgenesequencesshowsthatSNCGexpressionintulnorcelllinesismainlybecauseofactivatedtranscription，notgeneamplificationormutations[4]．Recentstudies
7、havefoundthatSNCGshowshi曲expressioninbreastCanCer嘲，IVAbstraetuterinecancer【叼，prostatecancer叼，pancreaticc鋤cer【s】，colorectalcancer19]andmanyothermalignancies，anditsabnormalexpressioniscloselyrelatedtotheclassificationandmalignantprogressoftumor．SNCGover-expressioncansti
8、mulatebreastcancercellproliferationandinducemetastasis【101．a(chǎn)ndCanbeusedasaIlindependentadverseprognosticfactorforbreastC．3nc
