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1、遵義醫(yī)學(xué)院碩士學(xué)位論文妊娠合并血小板減少癥的臨床分析姓名:陳蕾申請(qǐng)學(xué)位級(jí)別:碩士專業(yè):婦產(chǎn)科學(xué)指導(dǎo)教師:胡瓊201204遵義醫(yī)學(xué)院碩士學(xué)位論文妊娠合并血小板減少癥的臨床分析摘要目的:探討妊娠合并血小板減少癥的病因、處理及對(duì)母嬰的影響。方法:回顧性分析我院及遵義醫(yī)院2010年2月至2011年12月收治的144例妊娠期血小板減少患者的臨床資料,選擇同期144例血小板計(jì)數(shù)正常孕婦為對(duì)照組,比較其剖宮產(chǎn)率、產(chǎn)后出血率及新生兒窒息;妊娠相關(guān)性血小板減少癥的分布特點(diǎn)。結(jié)果:妊娠相關(guān)性血小板減少者最多,其次為特發(fā)性血小板減少性紫癜和妊娠期高血壓疾病,研究組剖宮產(chǎn)、產(chǎn)后出血、新生
2、兒窒息的發(fā)生率與對(duì)照組比較無(wú)統(tǒng)計(jì)學(xué)意義;PAT不需特殊治療,其他原因引起的血小板減少在治療原發(fā)病的基礎(chǔ)上,對(duì)血小板計(jì)數(shù)<50×109/L,有出血傾向時(shí),在終止妊娠前使用糖皮質(zhì)激素、丙種球蛋白、輸注血小板;研究組74例剖宮產(chǎn)中,14例選擇用全麻,60例選擇連續(xù)硬膜外麻醉,術(shù)后未出現(xiàn)硬膜外血腫等并發(fā)癥;妊娠相關(guān)性血小板減少癥的發(fā)病有地區(qū)差異。結(jié)論:妊娠相關(guān)性血小板減少是妊娠合并血小板減少的主要原因;妊娠相關(guān)性血小板減少癥的預(yù)后良好,不需特殊處理;妊娠合并血小板減少患者的分娩方式取決于血小板水平及產(chǎn)科指征:妊娠合并血小板減少剖宮產(chǎn)、產(chǎn)后出血及新生兒窒息的發(fā)生率與正常孕婦
3、相比無(wú)差異;仁懷市妊娠相關(guān)性血小板減少癥的發(fā)病率最高。關(guān)鍵詞:妊娠血小板減少妊娠結(jié)局4遵義醫(yī)學(xué)院碩士學(xué)位論文妊娠合并血小板減少癥的臨床分析ClinicalanalysisofpregnancywiththrombocytopeniaAbstractobjectiveTostudytheetiology,treatmentofthrombocytopeniainpregnancyanditsMethodsRetrospectiveanalysisof144casesofthrombocytopeniainpregnancyinourhospitalandZunyih
4、ospitalfromFebruary2010toDecember2011.Atthesametime,144pregnantwomenwithnormalamountofbloodplateletwereselectedascontrolgroup.Theincidencesofcesareansectionpostpartumhemorrhageandneonatalasphyxiawerecomparedbetweenthetwogroups.ResultsInthisstudy,pregnancy-relatedthrombocytopeniawasmos
5、tprevalentcauseofthrombocytopemainpregnancy,followedbyidiopathicthrombocytopenicpurpuraandhypertensivedisordercomplicatingpregnancyHowever,theincidencesofcesareansectionpostpartumhemorrhageandneonatalasphyxiainstudygroupdidnotdifferstatisticallyfromthecontrolgroup.PATdoesnotneedspecif
6、ictreatment.Thetreatmentofothercausesofthrombocytopeniashouldbaseonprimarydisease.Iftheamountofplateletislowerthan50x109/Landleadingtobleeding.Weshouldusecorticosteroids,immunoglobulinandplatelet.In74casesofCesareansection,14ofthemselectgeneralanesthesia,theotherselcetthecontinuousepi
7、duralanesthesia.Inallofthecases,noneofthemhavecomplicationssuchaspostoperativeepiduralhematoma.Ourstudyshowedthattheincidenceofpregnancy—relatedthrombocytopenia.CondusionPregnancy-relatedthrombocytopeniaistheprimarycausesofthrombocytoperdainpregnancy.Theprognosisisgoodanditdoesnotneed
8、speci