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1、碩士學(xué)位論文藤黃酸衍生物的合成及其抗腫瘤活性的研究TheSynthesisofGambogicAcidDerivativesandStudyonTheirAntitumorActivity專業(yè)：藥理學(xué)研究生：黎金海導(dǎo)師：黃雁教授廣州醫(yī)科大學(xué)·廣州二〇一四年五月萬(wàn)方數(shù)據(jù)目錄中英文詞匯對(duì)照表.................................................................1藤黃酸衍生物的合成及其抗腫瘤活性的研究...........................................2中文摘要...........
2、..............................................................2英文摘要.........................................................................3第一章研究背景..................................................................51.1藤黃酸的簡(jiǎn)介................................................................
3、.61.2藤黃酸及其衍生物的抗腫瘤機(jī)制.................................................71.2.1誘導(dǎo)細(xì)胞在G2/M期停滯..................................................71.2.2誘導(dǎo)細(xì)胞凋亡...........................................................81.2.3抑制端粒酶活性.........................................................91.2.4抗腫瘤血管
4、生成.........................................................91.2.5抗腫瘤轉(zhuǎn)移............................................................101.2.6逆轉(zhuǎn)腫瘤多藥耐藥......................................................101.2.7其他..................................................................101.2.8結(jié)語(yǔ).....
5、.............................................................111.3藤黃酸構(gòu)效關(guān)系及其衍生物合成的研究..........................................111.3.1藤黃酸的人工提取......................................................111.3.2C-9/10修飾衍生物的合成...............................................121.3.3C-30修飾衍生物的合成.......
6、..........................................121.3.4C-32,C-34修飾衍生物的合成............................................121.3.5C-35,C-37修飾衍生物的合成............................................131.3.6C-39修飾衍生物的合成.................................................131.3.7其他修飾衍生物的合成.........................
7、.........................131.4本課題研究的意義與前景.....................................................14第二章設(shè)計(jì)思想.................................................................152.1C-30位酰胺化引入官能基團(tuán)...............................................152.2氰基基團(tuán)的引入..........................
