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1、分類號學(xué)號D201078331校代碼10487密級博士學(xué)位論文p55PIK促進(jìn)腫瘤的血管生成及其機(jī)制研究申請人姓名：陳成學(xué)科專業(yè)：外科學(xué)指導(dǎo)教師：胡俊波教授答辯日期：2013年5月ADissertationSubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineThestudyofthemechanismofp55PIKpromotingtumorangiogenensisCandidate:ChenChengMajo
2、r:SurgeryDirectedby:Prof.HuJunboTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan,HubeiProvince,P.R.ChinaMay,2013獨創(chuàng)性聲明本人鄭重聲明，本學(xué)位論文是本人在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果的總結(jié)。盡我所知，除文中已經(jīng)標(biāo)明引用的內(nèi)容外，本論文不包含任何其他個人或集體已經(jīng)發(fā)表或撰寫過的研究成果。對本文的研究做出貢獻(xiàn)的個人和集體，均已在文中以明確方式標(biāo)明。本人完全意識到本人將承擔(dān)
3、本聲明引起的一切法律后果。學(xué)位論文作者簽名：日期：年月日學(xué)位論文版權(quán)使用授權(quán)書本學(xué)位論文作者完全了解學(xué)校有關(guān)保留、使用學(xué)位論文的規(guī)定，即：學(xué)校有權(quán)保留并向國家有關(guān)部門或機(jī)構(gòu)送交論文的復(fù)印件和電子版，允許論文被查閱和借閱。本人授權(quán)華中科技大學(xué)可以將本學(xué)位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫進(jìn)行檢索，可以采用影印、縮印或掃描等復(fù)制手段保存和匯編本學(xué)位論文。保密□，在_____年解密后適用本授權(quán)書。本論文屬于不保密□。（請在以上方框內(nèi)打“√”）學(xué)位論文作者簽名：指導(dǎo)教師簽名：日期：年月日日期：年月日目錄引言············
4、···················································································1全文摘要····························································································7ABSTRACT···········································································
5、············8第一部分p55PIK通過調(diào)控VEGF-A促進(jìn)腫瘤血管生成····························9摘要·······························································································9ABSTRACT······················································································11
6、前言·····························································································13實驗材料和儀器·················································································14實驗方法·········································································
7、·················15實驗結(jié)果··························································································26討論·····························································································36參考文獻(xiàn)················································
8、··········································39第二部分p55PIK通過NF-κB通路調(diào)控HIF-1α繼而促進(jìn)腫瘤血管生成······43摘要·····························································
