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1、AnAnalyticStudyoftheEffectsofAttenuationonTumorDetectioninWhole-BodyPETOncologyImagingChuanyongBai,PhD1;PaulE.Kinahan,PhD2;DavidBrasse,PhD3;ClaudeComtat,PhD4;DavidW.Townsend,PhD5;CarolynC.Meltzer,MD6;VictorVillemagne,MD7;MartinCharron,MD7;andMichelDefrise,PhD81Philips
2、MedicalSystems,ADACLaboratories,Milpitas,California;2DepartmentofRadiology,UniversityofWashington,Seattle,Washington;3InstitutdeRecherchesSubatomiques,InstitutNationaldePhysiqueNucle′aireetdePhysiquedesParticules,CentreNationaldelaRechercheScienti?que/Universite′Louis
3、Pasteur,Strasbourg,France;4DepartmentofMedicalResearch,ServiceHospitalierFre′de′ricJoliot,Commissariata`lEnergieAtomique,Orsay,France;5CancerImagingandTracerDevelopment,UniversityofTennesseeMedicalCenter,Knoxville,Tennessee;6DepartmentofRadiology,UniversityofPittsburg
4、h,Pittsburgh,Pennsylvania;7DepartmentofRadiology,ChildrensHospitalofPhiladelphia,Philadelphia,Pennsylvania;and8DivisionofNuclearMedicine,VrijeUniversiteitBrussel,Brussels,BelgiumTherehasbeenconsiderabledebateaboutthedesirabilityofTherehasbeenconsiderabledebateaboutthe
5、desirabilityattenuationcorrectioninwhole-bodyPEToncologyimaging.ofattenuationcorrectioninwhole-bodyPEToncologyim-Theadvantagesofattenuationcorrectionarequantitativeaccu-aging(14).Thesalientpointswerewellsummarizedinanracy,whereastheperceiveddisadvantagesarelossofcontr
6、ast,editorialbyWahl(5).Someperceivedadvantagesofrecon-noiseampli?cation,andincreasedscanningtime.Inthiswork,weexplaincontrastchangesbetweenimagesreconstructedstructingimageswithoutattenuationcorrectionareavoid-withandwithoutattenuationcorrection.Methods:Toanalyti-ance
7、ofthenoiseampli?cationinherentinattenuationcor-callyexplainbothwell-knownandsurprisingphenomenainrection(thiscancomefrom2sources,themultiplicativeimagesreconstructedwithoutattenuationcorrection,weper-effectoftheattenuationcorrectionandthenoiseinherentinformedaseriesof
8、simulationstudies,aphantomexperiment,thecorrectionfactorsthemselves);reductionofpatientandapatientexperiment.Results:Weshowe
