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1、獨獨創(chuàng)創(chuàng)性性聲聲明明秉承學校嚴謹?shù)膶W風與優(yōu)良的科學道德，本人聲明所呈交的論文是我個人在導師指導下進行的研究工作及取得的研究成果。盡我所知，除了文中特別加以標注和致謝的地方外，論文中不包含其他人已經(jīng)發(fā)表或撰寫過的研究成果，不包含本人或他人已申請學位或其他用途使用過的成果。與我一同工作的同志對本研究所做的任何貢獻均已在論文中作了明確的說明并表示了致謝。申請學位論文與資料若有不實之處，本人承擔一切相關(guān)責任。論文作者簽名：日期：保保護護知知識識產(chǎn)產(chǎn)權(quán)權(quán)聲聲明明本人完全了解第四軍醫(yī)大學有關(guān)保護知識產(chǎn)權(quán)的規(guī)定，即：研究生在校攻讀學位期間論文工作的知識產(chǎn)權(quán)單位屬第四軍醫(yī)大學。本人保證畢業(yè)離校后，發(fā)表
2、論文或使用論文工作成果時署名單位仍然為第四軍醫(yī)大學。學?？梢怨颊撐牡娜炕虿糠謨?nèi)容（含電子版，保密內(nèi)容除外），可以采用影印，縮印或其他復(fù)制手段保存論文。學校有權(quán)允許論文被查閱和借閱，并在校園網(wǎng)上提供論文內(nèi)容的瀏覽和下載服務(wù)。同意學校將論文加入《中國優(yōu)秀博碩士學位論文全文數(shù)據(jù)庫》和編入《中國知識資源總庫》，同意按《中國優(yōu)秀博碩士學位論文全文數(shù)據(jù)庫出版章程》規(guī)定享受相關(guān)權(quán)益。論文作者簽名：導師簽名：日期：EMMPRIN在涎腺腺樣囊性癌嗜神經(jīng)侵襲中的作用及機制研究研究生：楊新杰學科專業(yè)：口腔臨床醫(yī)學（頜外）所在單位：第四軍醫(yī)大學口腔醫(yī)院頜面外科導師：劉寶林教授（主任醫(yī)師）輔導教師：雷德林教
3、授（主任醫(yī)師）資助基金項目：第四軍醫(yī)大學博士學位論文課題資助（2010D14）關(guān)鍵詞：涎腺腺樣囊性癌；腫瘤侵襲；嗜神經(jīng)侵襲；EMMPRIN；MMPs；RNA干擾中國人民解放軍第四軍醫(yī)大學二O一二年五月博士學位論文目錄縮略語表·······································································································1中文摘要············································································
4、···························3ABSTRACT··································································································6前言·····································································································10文獻回顧····················································
5、·················································11文獻回顧一涎腺腺腺樣囊性癌嗜神經(jīng)侵襲的研究進展·························11文獻回顧二EMMPRIN在腫瘤中的相關(guān)作用研究進展··························17正文·····································································································22第一部分EMMPRIN在涎腺腺樣囊性癌的表達及意義············
6、··············221材料與方法·····················································································222結(jié)果································································································293討論···················································································
7、·············33第二部分EMMPRINSIRNA重組慢病毒載體的構(gòu)建及穩(wěn)定轉(zhuǎn)染細胞株的的篩選····················································································411材料與方法···············································································
