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《e-鈣粘蛋白基因多態(tài)性與子宮內(nèi)膜異位癥發(fā)病風(fēng)險的關(guān)聯(lián)性研究》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、授予單位代碼10089學(xué)號或申請?zhí)?0122362HebeiMedicalUniversity碩士學(xué)位論文科學(xué)學(xué)位E-鈣粘蛋白基因多態(tài)性與子宮內(nèi)膜異位癥發(fā)病風(fēng)險的關(guān)聯(lián)性研究研究生：李賓導(dǎo)師：康山教授李琰教授專業(yè)：婦產(chǎn)科學(xué)二級學(xué)院：第四醫(yī)院2015年3月河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師（或指導(dǎo)小組）的指導(dǎo)下，由本人獨立完成。本學(xué)位論文研究所獲得的研究成果，其知識產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對本學(xué)位論文進(jìn)行交流、公開和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文，
2、第一署名為單位河北醫(yī)科大學(xué)，試驗材料、原始數(shù)據(jù)、申報的專利等知識產(chǎn)權(quán)均歸河北醫(yī)科大學(xué)所有。否則，承擔(dān)相應(yīng)法律責(zé)任。tV研究生簽名:導(dǎo)師簽章：二級學(xué)院領(lǐng)導(dǎo)蓋章：7^/上年《月日河北醫(yī)科大學(xué)研究生學(xué)位論文獨創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果，除了文中特別加以標(biāo)注和致謝等內(nèi)容外，文中不包含其他人己經(jīng)發(fā)表或撰寫的研究成果，指導(dǎo)教師對此進(jìn)行了審定。本論文由本人獨立撰寫，文責(zé)自負(fù)。研究生簽名：導(dǎo)師簽章：？年名月”日目錄中文摘要······························
3、···············································1英文摘要·············································································5英文縮寫·············································································9研究論文E-鈣粘蛋白基因多態(tài)性與子宮內(nèi)膜異位癥發(fā)病風(fēng)險的關(guān)聯(lián)性研究前言····
4、·········································································10材料與方法····································································11結(jié)果·············································································18附圖··················
5、···························································21附表·············································································26討論·············································································30結(jié)論··························
6、···················································34參考文獻(xiàn)·······································································34綜述E-鈣粘蛋白與子宮內(nèi)膜異位癥相關(guān)不孕的研究進(jìn)展···············39致謝·············································································
7、······51個人簡歷·············································································52中文摘要E-鈣粘蛋白基因多態(tài)性與子宮內(nèi)膜異位癥發(fā)病風(fēng)險的關(guān)聯(lián)性研究摘要目的：子宮內(nèi)膜異位癥(Endometriosis，EMs)是育齡期婦女的常見疾病，臨床主要表現(xiàn)為進(jìn)行性加重的痛經(jīng)和不孕，嚴(yán)重影響育齡期婦女的健康和生育能力。目前，EMs的病因和發(fā)病機(jī)制仍不明確，普遍接受的是“子宮內(nèi)膜種植學(xué)說”。但是隨經(jīng)血逆流的子宮內(nèi)
8、膜碎片得以存活并致病，異位子宮內(nèi)膜細(xì)胞的侵襲、轉(zhuǎn)移能力對于異位病灶的形成起到了重要的作用。相關(guān)研究認(rèn)為，異位的子宮內(nèi)膜細(xì)胞可能通過上皮-間質(zhì)轉(zhuǎn)化獲得侵襲能力而參與EMs的發(fā)病過程。2+E-鈣粘蛋白（E-cadherin，CDH1）是上皮細(xì)胞表面Ca依賴性細(xì)胞粘附分子，主要參與形成上皮細(xì)胞之間的連接，是上皮細(xì)胞表面重要的分子標(biāo)志，其表達(dá)水平降低將引起上皮細(xì)胞間連接系統(tǒng)的異常，使細(xì)胞的活動性增加，是發(fā)生上皮-間質(zhì)轉(zhuǎn)化的重要標(biāo)志。相關(guān)研究證實，異位病灶處上皮細(xì)胞表面的E-cadherin
