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1、東南大學(xué)博士學(xué)位論文分子印跡聚合物的制備及在手性識(shí)別和手性拆分上的應(yīng)用姓名：李萍申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：生物醫(yī)學(xué)工程指導(dǎo)教師：袁春偉20030501摘要AbstractThemolecularlyimprintedpolymer(MIP)，whichisbeingdevelopedinrecentyears，isakindoferosslinkedmaterialwithfixedcavitiesshapeandarrangedfunctionalgroups．Becauseofitspredeterminativeandspecificmolecularre
2、cognitionability,aswellastheeasilypreparedabilityandIlighstability,theMIPcanbeusedwidelyinbiotechnology,clinicalmedicine．environmentalmonitoring．foodindustriesandsoon．TheM口alsoexhibitspromisingapplicationinracemoidresolutionwithchromatography,solid-phaseextraction，sensors，mimicenzym
3、ecatalystsandmembraneseparation．Inthisdissertation,MIPsaresynthesizedwitIlchiralsubstrates．suchasderivativesofphenylalanine，naproxenandderivativesofmandelicacid，astemplatestoinvestigatethepreparationofMIPsandtheirchiralrecognitionandchiralresolution．1．Introduction：Theessentialtheori
4、es，preparationtechnologiesandapplicationdevelopmentsofMrPsa∞r(nóng)eviewed．2．MIPsalesynthesizedwithL—phenylalanineethylester'L—phenylalanine1-hexylester,￡一phenylalaninecyclohexylesterandL-phenylalaninedodecaxylester∞templatesrespectively．Then，effectsoftheratiooffunctionalmonomerstotemplat
5、emolecules，thepolymerizationtemperatureandstructuresoftemplatesonthechiralresolutionofMIPsarestudied．ThestructureofL—phenylalaninacyclohexylesterissimulatedtoexplainthegoodchiralseparationcapabilityofrelativeMIP_Thechromatographicconditions，such∞mobilephases，concentrationsofsamplesa
6、ndtemperatureofcolumn，areoptimized．3．M1Pswithchiraldrug(S)-naproxenasthetemplatearepreparedwithdifferentfunctionalmonomers，crosslinkersandtheircontents，polymerizationsolution．TheresolutionabilitiesofMIPschiralstationaryphasearecompared．ThecavitiesinMIPsandthemorphologiesofMIPsarecha
7、racterizedusingliquidnitrogenadsorptionandscanningelectronicmicroscopy．ThebindingcapacityoftherS)-naproxenM碑isinvestigatedthrou曲bindingexpemnants．Scatchardanalysesshowthattherearetwoclassesofbindingsiteswithhi曲orlOWaffinityinMIPs，Thecomplexesformedby(S)-naproxenandfunctionalmonoersa
8、crylamidearesimulat
