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1、卵巢惡性上皮性腫瘤中HLA【關(guān)鍵詞】卵巢癌摘要目的：探討卵巢癌中HLADR抗原表達(dá)和樹突細(xì)胞浸潤的情況及其意義。方法：用免疫組化SP法對卵巢惡性上皮性腫瘤(48例)、良性上皮性腫瘤(30例)及正常卵巢(30例)的HLADR抗原表達(dá)及樹突細(xì)胞浸潤情況進(jìn)行對照研究。結(jié)果：正常卵巢組織中HLADR陰性,卵巢惡性上皮性腫瘤中HLADR表達(dá)陽性率為52.08％(P＜0.01)；HLADR表達(dá)率與腫瘤分化程度相關(guān)(P＜0.01)，且與預(yù)后相關(guān)(P＜0.05)；卵巢惡性上皮性腫瘤中樹突細(xì)胞(S100+DC)浸潤顯著增加(P＜0.001)；S100+DC浸潤與腫瘤間質(zhì)淋巴細(xì)胞浸潤相關(guān)(P＜0.01)；S
2、100+DC浸潤與腫瘤患者預(yù)后相關(guān)(P＜0.05)。結(jié)論：卵巢惡性上皮性腫瘤中HLADR抗原表達(dá)增強，樹突細(xì)胞浸潤增加，二者可能是局部抗腫瘤免疫的重要環(huán)節(jié)；HLADR和樹突細(xì)胞浸潤數(shù)量可作為提示卵巢癌患者預(yù)后的指標(biāo)。關(guān)鍵詞卵巢癌;預(yù)后;HLA抗原/免疫學(xué);S100蛋白;樹突細(xì)胞;免疫組織化學(xué)XIAOGuohong,CHENHuizhen,ZHANGGuiqing,ZHENGXiulingSecondMunicipalPeople'sHospital,GuangZhou，Guangdong510150AbstractObjective:Toinvestigatetheclinicaland
3、immunologicalsignificanceofHLADRantigenexpressionanddendriticcellinfiltrationinepithelialovariancancer.Method:Samplesof108casesincludingnormalovariantissue(n=30),benign(n=30)andmalignantepithelialovariantumor(n=48)wereusedinacomparativestudy.TheSPimmunohistochemicalstainmethodwasused.Result:HLADR
4、antigenpositiveratewassignificantlyhigherinthemalignantgroup(52.08%)thanthatinbenigngroup(10%)andinnormalgroup(0%)(P＜0.01).TherewasacorrelationbetweentheHLADRexpressionrateandthetumuordifferentiationandbetweenHLADRexpressionandtheprognosis.Thenumberofinfiltratingdendriticcells(S100+DC)wasmuchhigh
5、erinmalignant(538.17±255.01)thanthatinbenigngroup(345.96±226.81)andinnormalgroup(335.15±160.32)(P＜0.01).Therewasacorrelationbetweenthedendriticcell(S100+DC)infiltrationandtheintertumourlymphocyteinfiltration(P＜0.01)andtheprognosis(P＜0.05).Conclusion:ItwasshownthatHLADRantigenexpressionanddendriti
6、ccellsinfiltrationinepitherialovariancancerincreased,whichcouldplayaimportantroleinantitumourimmunity.TheexpressionofHLADRantigenandthegradeofdendriticcellsinfiltrationinepitherialovariancanceristheindicatorfortheprognosis.Keywordsovariancancer;HLADRantigen/immundogy;S100protein;dendriticcell;pro
7、gnosis;immunohistochemistry.人類主要組織相容性復(fù)合體即HLA(HumanLeukcuteAntigen),是迄今所發(fā)現(xiàn)的最復(fù)雜的基因復(fù)合體，它分別表達(dá)Ⅰ、Ⅱ、Ⅲ類抗原分子，HLADR是Ⅱ類抗原中表達(dá)最頻繁的一種。樹突細(xì)胞(dendriticcell,DC)是體內(nèi)主要的抗原提呈細(xì)胞，是T細(xì)胞依賴性免疫應(yīng)答的重要輔助細(xì)胞，通常表達(dá)S100蛋白，故稱為S100+DC。近年來HLA分子及S100+DC在腫瘤細(xì)胞免
